Mitochondrial K＋-ATP （mito-KATP） channels play an important role in cellular function and survival following ischemic stress. The present results revealed that intervention with diazoxide, a mito-KATP channel opene...Mitochondrial K＋-ATP （mito-KATP） channels play an important role in cellular function and survival following ischemic stress. The present results revealed that intervention with diazoxide, a mito-KATP channel opener, led to an increase in Bcl-2 expression in the cerebral cortex of rats subjected to cerebral ischemia reperfusion injury. In addition, the intervention also led to clear improvements in neuronal mitochondrial morphology and consciousness post-injury. Glibenclamide a mito-KATP channel blocker, exhibited the converse effects. Both diazoxide and glibenclamide exerted dose-dependent effects （in particular, at 18 mg/kg diazoxide and 25 mg/kg glibenclamide）. These findings suggest that diazoxide exerts a neuroprotective effect on cerebral ischemia reperfusion injury by opening mito-KATP channels and upregulating Bcl-2 expression.展开更多
In this work,MIL-101,a metal organic framework,has been synthesized and examined in the adsorptive denitrogenation process.Due to the importance of adsorption capacity and selectivity,the effects of synthesis paramete...In this work,MIL-101,a metal organic framework,has been synthesized and examined in the adsorptive denitrogenation process.Due to the importance of adsorption capacity and selectivity,the effects of synthesis parameters including metal type,reagent ratio,time and temperature on the MIL-101 performance were investigated by measuring quinoline(QUI)separation from iso-octane.The optimum conditions were determined using a Taguchi experimental design and the multiresponse optimization(multivariate statistical)method.Based on the arithmetic mean of normalized QUI adsorption capacity and QUI/dibenzothiophene(DBT)selectivity,as the objective function,the optimum value of synthesis parameters were found to be manganese as metal type in the structure,180°C for synthesis temperature,15h for synthesis time and 1.00 for reagent molar ratio.Under these conditions,QUI adsorption capacity and QUI/DBT selectivity were 19.3 mg-N/g-Ads.and 24.6,respectively.Accordingly,the arithmetic mean between normalized values of these measured parameters was equal to 1.10,which is in good agreement with the predicted value.The MIL-101 produced under optimum conditions was characterized by determining its specific surface area,X-ray powder diffraction patterns and Fourier transform infrared spectroscopy.Finally,isotherm and kinetic studies indicate that the Langmuir isotherm and pseudo-first-order model can successfully describe the experimental data.展开更多
文摘Mitochondrial K＋-ATP （mito-KATP） channels play an important role in cellular function and survival following ischemic stress. The present results revealed that intervention with diazoxide, a mito-KATP channel opener, led to an increase in Bcl-2 expression in the cerebral cortex of rats subjected to cerebral ischemia reperfusion injury. In addition, the intervention also led to clear improvements in neuronal mitochondrial morphology and consciousness post-injury. Glibenclamide a mito-KATP channel blocker, exhibited the converse effects. Both diazoxide and glibenclamide exerted dose-dependent effects （in particular, at 18 mg/kg diazoxide and 25 mg/kg glibenclamide）. These findings suggest that diazoxide exerts a neuroprotective effect on cerebral ischemia reperfusion injury by opening mito-KATP channels and upregulating Bcl-2 expression.
文摘In this work,MIL-101,a metal organic framework,has been synthesized and examined in the adsorptive denitrogenation process.Due to the importance of adsorption capacity and selectivity,the effects of synthesis parameters including metal type,reagent ratio,time and temperature on the MIL-101 performance were investigated by measuring quinoline(QUI)separation from iso-octane.The optimum conditions were determined using a Taguchi experimental design and the multiresponse optimization(multivariate statistical)method.Based on the arithmetic mean of normalized QUI adsorption capacity and QUI/dibenzothiophene(DBT)selectivity,as the objective function,the optimum value of synthesis parameters were found to be manganese as metal type in the structure,180°C for synthesis temperature,15h for synthesis time and 1.00 for reagent molar ratio.Under these conditions,QUI adsorption capacity and QUI/DBT selectivity were 19.3 mg-N/g-Ads.and 24.6,respectively.Accordingly,the arithmetic mean between normalized values of these measured parameters was equal to 1.10,which is in good agreement with the predicted value.The MIL-101 produced under optimum conditions was characterized by determining its specific surface area,X-ray powder diffraction patterns and Fourier transform infrared spectroscopy.Finally,isotherm and kinetic studies indicate that the Langmuir isotherm and pseudo-first-order model can successfully describe the experimental data.
