Application and Prospect of Mixed Reality Technology in Medical Field

Mixed reality(MR)technology is a new digital holographic image technology,which appears in the field of graphics after virtual reality(VR)and augmented reality(AR)technology,a new interdisciplinary frontier.As a new generation of technology,MR has attracted great attention of clinicians in recent years.The emergence of MR will bring about revolutionary changes in medical education training,medical research,medical communication,and clinical treatment.At present,MR technology has become the popular frontline information technology for medical applications.With the popularization of digital technology in the medical field,the development prospects of MR are inestimable.The purpose of this review article is to introduce the application of MR technology in the medical field and prospect its trend in the future.

Application of Virtual Reality Technology in Disaster Medicine

The occurrence of major emergencies often leads to environmental damage,property damage,health challenges and life threats.Despite the tremendous progress we have made in responding to the many challenges posed by disasters in recent years,there are still many shortcomings.As an emerging technology widely used in recent years,virtual reality(VR)technology is very suitable for many fields of disaster medicine,such as basic education,professional training,psychotherapy,etc.The purpose of this review article is to introduce the application of VR technology in the disaster medical field and prospect its trend in the future.

Erratum to:Application of Virtual Reality Technology in Disaster Medicine

The article“Application of Virtual Reality Technology in Disaster Medicine”,written by Yu-yu DUAN,Jia-yao ZHANG,Mao XIE,Xiao-bo FENG,Song XU,Zhe-wei YE,was originally published electronically on the publisher’s internet portal on October 2019 without open access.With the author(s)’decision to opt for Open Choice,the copyright of the article is changed to©The Author(s)2020 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License(https://creativecommons.org/licenses/by/4.0/),which permits use,sharing,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source,provide a link to the Creative Commons license,and indicate if changes were made.

Traumatic brain injury stimulates sympathetic tone-mediated bone marrow myelopoiesis to favor fracture healing

Traumatic brain injury(TBI)accelerates fracture healing,but the underlying mechanism remains largely unknown.Accumulating evidence indicates that the central nervous system(CNS)plays a pivotal role in regulating immune system and skeletal homeostasis.However,the impact of CNS injury on hematopoiesis commitment was overlooked.Here,we found that the dramatically elevated sympathetic tone accompanied with TBI-accelerated fracture healing;chemical sympathectomy blocks TBIinduced fracture healing.TBI-induced hypersensitivity of adrenergic signaling promotes the proliferation of bone marrow hematopoietic stem cells(HSCs)and swiftly skews HSCs toward anti-inflammation myeloid cells within 14 days,which favor fracture healing.Knockout ofβ3-orβ2-adrenergic receptor(AR)eliminate TBI-mediated anti-inflammation macrophage expansion and TBIaccelerated fracture healing.RNA sequencing of bone marrow cells revealed that Adrb2 and Adrb3 maintain proliferation and commitment of immune cells.Importantly,flow cytometry confirmed that deletion ofβ2-AR inhibits M2 polarization of macrophages at 7th day and 14th day;and TBI-induced HSCs proliferation was impaired inβ3-AR knockout mice.Moreover,β3-andβ2-AR agonists synergistically promote infiltration of M2 macrophages in callus and accelerate bone healing process.Thus,we conclude that TBI accelerates bone formation during early stage of fracture healing process by shaping the anti-inflammation environment in the bone marrow.These results implicate that the adrenergic signals could serve as potential targets for fracture management.

Mixed reality assists the fight against COVID-19

Coronavirus disease 2019(COVID-19)made a huge effect globally.With the assistance of mixed reality(MR)technology,complicated clinical works became easier to carry out and the condition had been greatly improved with high-tech advantages such as improved convenience,better understanding and communication,higher security,and medical resource saving.This study aimed to introduce one kind of MR application in the fight against COVID-19 and anticipate more feasible smart healthcare applications to enhance our strength for the final victory.