Low-dose intralesional injection of 5-fluorouracil and triamcinolone reduces tissue resident memory T cells in chronic eczema

BACKGROUND Tissue resident memory T(TRM)cells have been reported to play a significant role in the pathogenesis and relapse of chronic eczema.AIM To compare the efficacy and safety of the intralesional injection of 5-fluorouracil(5-FU)and triamcinolone(TA)with those associated with TA alone for the treatment of chronic eczema.METHODS A total of 168 patients were randomized to 5-FU+TA or TA groups and received a one-time intralesional injection of 5-FU+TA or TA only.Biopsies were collected before and 2 wk after treatment for evaluation of histopathological changes.All patients were followed up monthly for up to 1 year.RESULTS No serious adverse event was observed in either group.Although the mean atopic dermatitis severity index scores and effective rates were comparable between the two groups after 2 wk of treatment,the relapse rate was significantly lower in the 5-FU+TA group than in the TA group.Histological examination showed significantly fewer CD8^(+)and CD103^(+)T cells but not CD4^(+)T cells in the 5-FU+TA group.CONCLUSION One-time intralesional injection of 5-FU+TA is effective and safe for chronic eczema treatment and can further reduce the retention of T_(RM) cells in the lesional skin and the relapse rate of chronic eczema.

Local hydraulic jump effects on sediment deposition in open-channel flume experiments

When a river channel is narrow,bifurcated,or intersected,or when extreme weather or geological disasters cause shed rock masses to occupy a river flood channel,local hydraulic jumps may develop in the channel.Natural disasters such as landslides,floods,and debris flows occur upstream,will result in large transport rate of large-sized gravel particles.Those particles may be blocked in hydraulic jump areas,causing river channel water depth to rise.In this study,the effect of local hydraulic jumps on the sediment deposition rate was investigated in flume experiments.The ratio of upstream and downstream Froude numbers,particle size,Sediment supply intensity,and flow discharge all affected the sediment deposition rate.With increases in the ratio of upstream and downstream Froude numbers,particle size,and sediment supply intensity,the sediment deposition rate increased.The sediment deposition rate decreased with an increase in flow discharge.Approach hydraulic conditions and particle properties jointly determined the sediment deposition rate in a hydraulic jump section,and an empirical formula was developed using those parameters to calculate the sediment deposition rate.Thus,to identify risks and prevent disasters in mountain rivers,local changes in hydraulic conditions and particle properties need to be jointly evaluated.

Air bubble breakup in shear water flows generated by a plug conduit:An experimental investigation

In the context of a sudden contraction plug conduit,the near-wall area experiences a significant shearing effect of water flow,however,the extent to which this shearing effect occurs in bubble-water flow and the related variation mechanisms of air bubble size and number remain unclear.This study employs a model test method to investigate the diffusion process of bubble-water flow in a sudden contraction plug conduit.The size and number of bubbles,as well as their distribution along the shearing section under varying initial air volume conditions,are studied in detail using a high-speed image acquisition system.The experimental findings reveal a self-similar relationship between the number and size of bubbles and their cross-sectional distribution over time.The bubble number and size vary in three stages,i.e.,quasi-suspension,shearing,and shearing completion stages.The direction perpendicular to the conduit exhibits peak values in bubble number distribution over the three stages,with peak value location varying with the near-wall area.As time progresses,the peak value increases,and a larger initial air volume corresponds to a smaller distance of the peak value location from the wall.The size of air bubbles near the wall is consistent with the minimum diameter of air bubbles in shear flow and is hardly affected by the initial air volume.These results aid in comprehending the change law of two-phase water and air flow under a strong shearing effect in the plug conduit,and provide useful insights for hydraulic design in fluid engineering.