A facile and sustainable approach for the amination of benzothiazoles with KSe CN using iodine as the catalyst in water has been disclosed under transition-metal free conditions. The reaction proceeded smoothly to aff...A facile and sustainable approach for the amination of benzothiazoles with KSe CN using iodine as the catalyst in water has been disclosed under transition-metal free conditions. The reaction proceeded smoothly to afford various primary 2-amino benzothiazoles in up to 96% yield. A series of control experiments were performed, suggesting a ring-opening mechanism was involved via a radical process. This protocol provides efficient synthesis of primary 2-aminobenzothiazoles.展开更多
基金Financial support from the National Natural Science Foundation of China (Nos. 21672192, 21803059, and U1904212)。
文摘A facile and sustainable approach for the amination of benzothiazoles with KSe CN using iodine as the catalyst in water has been disclosed under transition-metal free conditions. The reaction proceeded smoothly to afford various primary 2-amino benzothiazoles in up to 96% yield. A series of control experiments were performed, suggesting a ring-opening mechanism was involved via a radical process. This protocol provides efficient synthesis of primary 2-aminobenzothiazoles.
