高危新生儿视网膜黄斑出血与屈光发育异常的相关性研究

目的:探讨高危新生儿视网膜黄斑出血与屈光异常的关系,并分析屈光发育异常的影响因素。方法:对2017-01/2018-01在我院新生儿科住院的高危新生儿1229例2458眼于出生后7d内进行RetCamⅢ眼底照像检查,并于1~1.5岁进行屈光筛查,分析高危新生儿屈光发育异常的影响因素。结果:本研究纳入高危新生儿中视网膜出血未累及黄斑者205眼(A组),其中屈光异常者6眼(2.93%);视网膜出血累及黄斑者57眼(B组),其中屈光异常者17眼(29.82%);无视网膜出血者2196眼(C组),其中屈光异常者40眼(1.82%),B组患儿屈光异常率高于A组和C组(均P<0.001),而A组与C组之间无差异(P=0.27)。Logistic回归分析结果显示,黄斑出血、缺血缺氧性脑病是屈光发育异常的独立危险因素。结论:视网膜黄斑区出血的新生儿中屈光发育异常率较高,黄斑出血和缺血缺氧性脑病是导致屈光发育异常的独立危险因素,应针对此类新生儿群体加强观察和干预。

Stochastic averaging of quasi partially integrable Hamiltonian systems under fractional Gaussian noise

A stochastic averaging method for predicting the response of quasi partially integrable and non-resonant Hamiltoniansystems to fractional Gaussian noise （fGla） with the Hurst index 1/2〈H〈l is proposed. The averaged stochastic differential equa-tions （SDEs） for the first integrals of the associated Hamiltonian system are derived. The dimension of averaged SDEs is less thanthat of the original system. The stationary probability density and statistics of the original system are obtained approximately fromsolving the averaged SDEs numerically. Two systems are worked out to illustrate the proposed stochastic averaging method. It isshown that the results obtained by using the proposed stochastic averaging method and those from digital simulation of originalsystem agree well, and the computational time for the former results is less than that for the latter ones.