Application of Kaiser Sepsis Calculator in culture-positive infants with early onset sepsis

Background Kaiser Sepsis Calculator(KSC)reduces antibiotic use,testing and intravenous infiltrates but there are concerns about the missed early onset sepsis(EOS)cases.We sought to apply the KSC score for culture-positive infants retrospectively in infants born in the last 10 years in our hospital.Methods In a retrospective cohort study,the comparison groups were divided into Group A(no antibiotics recommended by KSC)and Group B(antibiotics recommended).Results Overall,17/24(71%)infants would have been started on antibiotics per KSC but 7/24(29%)would not.The initial EOS risk was not significantly different between the groups(Group A vs.Group B:0.44 vs.0.76,P=0.41),but the final risk score was(0.33 vs.9.41,P<0.001).In Group A(no antibiotics),3/7 infants became symptomatic between 9 and 42 hours.Conclusion There may be a potential delay in starting antibiotics in infants that are asymptomatic at birth while using KSC.

Improving health care usage in a very low birth weight population

Background:Prematurity is the biggest contributor to admissions in the neonatal intensive care unit(NICU).The period following hospital discharge is a vital continuum for the very low birth weight(VLBW)infant The objective of this study was to assess the impact of a unique discharge and follow-up process on the outcomes of VLBW infants leaving the NICU.Methods:All outpatient health care usage by VLBW infants born in the study year(cases)was retrospectively tracked through 12 months of age.A cohort of healthy newborn infants were matched by birthdate to each VLBW infant(controls)and similarly tracked.Results:In this study,there were 85 cases and 85 controls.The mean gestational age at birth for the cases was 29.1±2.7 weeks with a mean birth weight of 1079±263 g.That of the controls was 38.9±13 weeks and 3202±447 g.Over 90%of both populations had Medicaid coverage.All VLBW infants received care at the Special Care Developmental Follow-Up Clinic.When compared with the controls,VLBW infants discharged from the NICU made fewer acute,unscheduled visits to the Emergency Department or Urgent Care Clinic(2.3±2.5 vs.3.7±3.5;P=0.007)despite their high-risk medical and social status.Their growth pattern showed significant"catch-up"and was similar to the matched controls at the last scheduled visit for each group.Conclusions:Outcomes including health care utilization in high-risk infants can be improved through meticulous discharge planning and follow-up measures that utilize existing hospital infrastructure to provide affordable comprehensive care.