Double-face urethroplasty in patients with obliterative bulbar strictures post-transurethral resection of the prostate mid-term outcomes in high-volume referral center

Objective Incidences of post-transurethral resection of the prostate(post-TURP)strictures are between 2.2%and 9.8%.Stricture commonly occurs within the first 6 months.Our objective was to assess the outcomes of patients with obliterative strictures post-TURP that underwent a double-face urethroplasty.Methods This is a single-center prospective study of 17 patients with obliterative proximal bulbar stricture post-TURP who underwent double-face graft urethroplasty by two surgeons between January 2014 and January 2020.We defined post-TURP obliterative strictures as those patients who presented with complete or almost complete obstruction of the urethral lumen and who have had a history of acute urine retention.We have excluded patients with bladder neck contracture.Primary outcome was treatment success,defined as the no need for further treatments.Secondary outcome was post-urethroplasty continent rate.Results Seventeen patients were included in the study with median age of 66(interquartile range 40-77)years;median time of follow-up was 24(interquartile range 12-84)months;median stricture length was 4(interquartile range 2-6)cm.Of the 17 patients,15(88.2%)were successful.All patients were continent after urethroplasty.Conclusion With mid-term follow-up,treatment of obliterative proximal bulbar strictures with double-face buccal mucosa graft is a safe and effective procedure.Obliterative proximal bulbar strictures merit double-face urethroplasty with high-rate success and functional outcomes.

Graphene-Oxide Mediated Chemodivergent Ring-Opening of Cyclobutanols

The chemodivergent ring-opening of cyclobutanols is described under the carbocatalytic assistance of graphene oxide(GO).The protocol enables the synthesis of diversely functionalized dienes or indenes(26 examples)based on the amount of GO employed.Spectroscopic(XPS and ssNMR)as well as experimental investigations revealed a direct involvement of theπ-domains of GO in tuning the stability of carbocationic intermediates during the reaction.

Nickel Catalyzed Functionalization of Allenes

What is the most favorite and original chemistry developed in your research group?The stereoselective gold catalyzed manipulation of in doles with n-alcohols.How do you get into this specific field? Could you please share some experiences with our readers?Step-by-step. Specifically, by merging our background on catalytic alkylation of arenes with an emerging area (at that time) such as homogeneous gold catalysis.What is the most important personality for a researcher?? Leadership, attitude in motivating early-stage scientists and capability of combining scientific inputs of different heritage for a single and ultimate goal.

Recent Advances in the Catalytic Functionalization of “Electrophilic” Indoles

When "dark"is bright:the scarcely explored electrophilic profile of the indolyl core(dark side)continues to inspire developments in organic synthesis by means of new catalytic methodologies.Recent advancements in the field enabled molecular diversity and complexity to be effectively realized within heterocyclic chemistry.

Tandem Functionalization-Carboxylation Reactions ofπ-Systems with CO_(2)

The tandem catalytic functionalization/carboxylation of double as well as triple carbon-carbon bonds with CO_(2) represent an emerging research area in synthetic organic methodology.In particular,the combination of mild reaction conditions,stoichiometric acceptor/donorless conditions(visible light photoredox catalysis)and chiral catalysts contributed to a rapid development of this intriguing research area capable of creating chemical diversity/complexity from readily available unsaturated hydrocarbons and CO2 as a C1-buinding block.The most recent developments in the field have been collected in the present review article and organized,based on the different sets ofπ-systems/intermediates/reactive partners employed(i.e.,nickelalactones,organo-halides)as well as synthetic strategies(i.e.,visible-light photo redox catalysis).

Flaps for bulbar urethral ischemic necrosis in pelvic fracture urethral injury

Bulbar urethral ischemic necrosis(BUIN)is an iatrogenic entity resulting from repeated attempts at performing anastomotic urethroplasty for pelvic fracture urethral injuries.Etiologically speaking,BUIN is related to a compromised blood supply of the bulbar urethra,which normally relies on anterograde supply from bulbar arteries and retrograde supply from recurrent branches of dorsal penile arteries,through the glans.At each transection of the bulbar urethra,both the anterograde and retrograde supplies are compromised,increasing the risk of BUIN.Even though this term is widely used among reconstructive urologists,BUIN is orphan of an accepted scientific definition.We aim to report our personal perspective on BUIN,to identify factors associated with its occurrence,and to describe the management options in these patients.