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Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host 被引量:1
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作者 Vitor Sueth-Santiago Debora Decote-Ricardo +2 位作者 Alexandre Morrot Celio Geraldo freire-de-lima marco edilson freire lima 《World Journal of Biological Chemistry》 CAS 2017年第1期57-80,共24页
Almost 110 years after the first studies by Dr. Carlos Chagas describing an infectious disease that was named for him, Chagas disease remains a neglected illness and a death sentence for infected people in poor countr... Almost 110 years after the first studies by Dr. Carlos Chagas describing an infectious disease that was named for him, Chagas disease remains a neglected illness and a death sentence for infected people in poor countries. This short review highlights the enormous need for new studies aimed at the development of novel and more specific drugs to treat chagasic patients. The primary tool for facing this challenge is deep knowledge about the similarities and differences between the parasite and its human host. 展开更多
关键词 Trypanosoma cruzi Trans-sialidase Trypanothione reductase CYP51 Cruzipain TUBULIN
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