An uncatalyzed and easily accessible synthetic approach for the preparation of 3-aroylindoles was investigated using nitrosoarenes and aromatic terminal ethynyl ketones. Indole derivatives were produced in good yields...An uncatalyzed and easily accessible synthetic approach for the preparation of 3-aroylindoles was investigated using nitrosoarenes and aromatic terminal ethynyl ketones. Indole derivatives were produced in good yields and excellent regioselectivity. Functionalizations of the indole products were carried out affording highly valuable and versatile compounds. The indolization protocol was studied as a fundamental step for the preparation of pravadoline and 1-butyl-3-(1-naphthoyl)indole (JWH-073), bioactive molecules showing antinociceptic properties.展开更多
Night cooling of building is considered as a technology with a high potential of impact on air conditioning energy needs. Natural ventilation should be the first option for night cooling, for obvious reasons of energy...Night cooling of building is considered as a technology with a high potential of impact on air conditioning energy needs. Natural ventilation should be the first option for night cooling, for obvious reasons of energy savings. The evaluation of the capacity of the building to cool down its structures during night ventilation is of primary concern during preliminary design stage, even though night cooling with natural ventilation is among the most complex problem to be modelled in details. Some modelling options are available, assuming different simplifications in space and time. Among them, virtual sphere modelling has been proposed in the past as a quick way to perform dynamic simulation of the night cooling of buildings. In this paper, the theoretical origin of the virtual sphere model is recalled, underlining its limits in case of application to buoyancy driven night cooling of buildings. The limits can explain the disagreements of virtual sphere prediction with other methods reported in literature and may stimulate a more conscious application of the model and further improvements of the method.展开更多
文摘An uncatalyzed and easily accessible synthetic approach for the preparation of 3-aroylindoles was investigated using nitrosoarenes and aromatic terminal ethynyl ketones. Indole derivatives were produced in good yields and excellent regioselectivity. Functionalizations of the indole products were carried out affording highly valuable and versatile compounds. The indolization protocol was studied as a fundamental step for the preparation of pravadoline and 1-butyl-3-(1-naphthoyl)indole (JWH-073), bioactive molecules showing antinociceptic properties.
文摘Night cooling of building is considered as a technology with a high potential of impact on air conditioning energy needs. Natural ventilation should be the first option for night cooling, for obvious reasons of energy savings. The evaluation of the capacity of the building to cool down its structures during night ventilation is of primary concern during preliminary design stage, even though night cooling with natural ventilation is among the most complex problem to be modelled in details. Some modelling options are available, assuming different simplifications in space and time. Among them, virtual sphere modelling has been proposed in the past as a quick way to perform dynamic simulation of the night cooling of buildings. In this paper, the theoretical origin of the virtual sphere model is recalled, underlining its limits in case of application to buoyancy driven night cooling of buildings. The limits can explain the disagreements of virtual sphere prediction with other methods reported in literature and may stimulate a more conscious application of the model and further improvements of the method.
