The immunological aspects of autoantibodies directed against paranodal and nodal proteins form a prominent field of research.Contactin-1 and contactin-1 associated protein,gliomedin and neurofascin(NF)are Ranvier node...The immunological aspects of autoantibodies directed against paranodal and nodal proteins form a prominent field of research.Contactin-1 and contactin-1 associated protein,gliomedin and neurofascin(NF)are Ranvier node-related proteins[1,2].Antibodies against these proteins have been identified in chronic demyelinating conditions,such as multiple sclerosis(MS)and chronic inflammatory demyelinating polyradiculoneuropathy(CIDP);and in acute demyelinating diseases such as Guillain-Barre syndrome[3,4].Myelin and the paranodal axoglial junctions flanking the nodes of Ranvier are not merely passive transmitters of electric signals:instead,they have essential roles in maintaining the structural integrity of myelin-axolemmal interactions,bidirectional signaling and regulation of ion channels[5].展开更多
文摘The immunological aspects of autoantibodies directed against paranodal and nodal proteins form a prominent field of research.Contactin-1 and contactin-1 associated protein,gliomedin and neurofascin(NF)are Ranvier node-related proteins[1,2].Antibodies against these proteins have been identified in chronic demyelinating conditions,such as multiple sclerosis(MS)and chronic inflammatory demyelinating polyradiculoneuropathy(CIDP);and in acute demyelinating diseases such as Guillain-Barre syndrome[3,4].Myelin and the paranodal axoglial junctions flanking the nodes of Ranvier are not merely passive transmitters of electric signals:instead,they have essential roles in maintaining the structural integrity of myelin-axolemmal interactions,bidirectional signaling and regulation of ion channels[5].
