As an endocrine hormone,vitamin D plays an important role in bone health and calcium homeostasis.Over the past two decades,the non-calcemic effects of vitamin D were extensively examined.Although the effect of vitamin...As an endocrine hormone,vitamin D plays an important role in bone health and calcium homeostasis.Over the past two decades,the non-calcemic effects of vitamin D were extensively examined.Although the effect of vitamin D on beta cell function were known for some time,the effect of vitamin D on glucose and fuel homeostasis has attracted new interest among researchers.Yet,to date,studies remain inconclusive and controversial,in part,due to a lack of understanding of the threshold effects of vitamin D.In this review,a critical examination of interventional trials of vitamin D in prevention of diabetes is provided.Like use of vitamin D for bone loss,the benefits of vitamin D supplementation in diabetes prevention were observed in vitamin D-deficient subjects with serum 25-hydroxyvitamin D<50 nmol/L(20 ng/mL).The beneficial effect from vitamin D supplementation was not apparent in subjects with serum 25-hydroxyvitamin D>75 nmol/L(30 ng/mL).Furthermore,no benefit was noted in subjects that achieved serum 25-hydroxyvitamin D>100 nmol/L(40 ng/mL).Further studies are required to confirm these observations.展开更多
文摘As an endocrine hormone,vitamin D plays an important role in bone health and calcium homeostasis.Over the past two decades,the non-calcemic effects of vitamin D were extensively examined.Although the effect of vitamin D on beta cell function were known for some time,the effect of vitamin D on glucose and fuel homeostasis has attracted new interest among researchers.Yet,to date,studies remain inconclusive and controversial,in part,due to a lack of understanding of the threshold effects of vitamin D.In this review,a critical examination of interventional trials of vitamin D in prevention of diabetes is provided.Like use of vitamin D for bone loss,the benefits of vitamin D supplementation in diabetes prevention were observed in vitamin D-deficient subjects with serum 25-hydroxyvitamin D<50 nmol/L(20 ng/mL).The beneficial effect from vitamin D supplementation was not apparent in subjects with serum 25-hydroxyvitamin D>75 nmol/L(30 ng/mL).Furthermore,no benefit was noted in subjects that achieved serum 25-hydroxyvitamin D>100 nmol/L(40 ng/mL).Further studies are required to confirm these observations.
