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Synthesis of different-sized gold nanostars for Raman bioimaging and photothermal therapy in cancer nanotheranostics 被引量:2
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作者 Jie Gao maria sanchez-purra +6 位作者 Hao Huang ShunhaoWang Yunan Chen Xuefeng Yu Qian Luo Kimberly Hamad-Schifferli Sijin Liu 《Science China Chemistry》 SCIE EI CAS CSCD 2017年第9期1219-1229,共11页
Gold nanoparticles(AuNPs) have been attractive for nanomedicine because of their pronounced optical properties.Here,we customerized the methods to synthesize two types of gold nanostars,Au nanostars-1 and Au nanostars... Gold nanoparticles(AuNPs) have been attractive for nanomedicine because of their pronounced optical properties.Here,we customerized the methods to synthesize two types of gold nanostars,Au nanostars-1 and Au nanostars-2,which have different spire lengths and optical properties,and also spherical AuNPs.Compared to nanospheres,gold nanostars were less toxic to a variety of cells,including macrophages.Au nanostars-1 and Au nanostars-2 also manifested a similar pattern of tissue distribution upon in vivo administration in mice to that of nanospheres,and but reveled less liver retention than nanospheres.Due to their strong absorption in the near-infrared(NIR),Au nanostars-2 induced a strong hyperthermia effect in vitro upon excitation at 808 nm,and elicited a robust photothermal therapy(PTT) efficacy in ablating tumors in a mouse model of orthotopic breast cancer using 4T1 breast cancer cells.Meanwhile,Au nanostars-1 showed a great capability to enhance the Raman signal through surface-enhanced Raman spectroscopy(SERS) in 4T1 cells.Our combined results opened a new avenue to develop Au nanostars for cancer imaging and therapy. 展开更多
关键词 GOLD nanoparticle nanostar surface PLASMON resonance tissue distribution TOXICITY profile
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