Bilirubin,the primary breakdown product of hemoproteins,particularly hemoglobin,plays a key role in the diagnosis,prognosis,and monitoring of liver diseases.In acute liver dis-eases,such as acute liver failure,drug-in...Bilirubin,the primary breakdown product of hemoproteins,particularly hemoglobin,plays a key role in the diagnosis,prognosis,and monitoring of liver diseases.In acute liver dis-eases,such as acute liver failure,drug-induced liver injury,and viral hepatitis,bilirubin serves as a biomarker reflecting the extent of hepatocyte loss and liver damage.Chronic liver diseases,including alcohol-related liver disease,chronic hep-atitis C virus infection,metabolic dysfunction-associated fat-ty liver disease,and autoimmune liver diseases,are marked by persistent liver injury and inflammation.Bilirubin levels in chronic liver diseases provide insight into liver function,disease severity,and prognosis.As a versatile biomarker,bilirubin offers valuable information on the pathophysiology of liver diseases and aids in guiding clinical decision-making regarding the treatment of liver diseases and their complica-tions.This review aimed to explore the multifunctional role of bilirubin in liver diseases by analyzing its biological functions beyond its role as a biomarker of liver damage.展开更多
文摘Bilirubin,the primary breakdown product of hemoproteins,particularly hemoglobin,plays a key role in the diagnosis,prognosis,and monitoring of liver diseases.In acute liver dis-eases,such as acute liver failure,drug-induced liver injury,and viral hepatitis,bilirubin serves as a biomarker reflecting the extent of hepatocyte loss and liver damage.Chronic liver diseases,including alcohol-related liver disease,chronic hep-atitis C virus infection,metabolic dysfunction-associated fat-ty liver disease,and autoimmune liver diseases,are marked by persistent liver injury and inflammation.Bilirubin levels in chronic liver diseases provide insight into liver function,disease severity,and prognosis.As a versatile biomarker,bilirubin offers valuable information on the pathophysiology of liver diseases and aids in guiding clinical decision-making regarding the treatment of liver diseases and their complica-tions.This review aimed to explore the multifunctional role of bilirubin in liver diseases by analyzing its biological functions beyond its role as a biomarker of liver damage.
