Background:Crohn’s disease,described by Dr.Burrill Crohn and his colleagues in 1932,continues to be of great research and clinical interest.It was initially perceived as a distinct condition and it has evolved since ...Background:Crohn’s disease,described by Dr.Burrill Crohn and his colleagues in 1932,continues to be of great research and clinical interest.It was initially perceived as a distinct condition and it has evolved since into a complex disease,with debates still going regarding its classification and etiology.Even though more that 80 years of research have passed,numerous significant questions regarding the disease’s causes and best possible treatment strategies still remain.Methods:This article reviews both historical and contemporary perspectives on Crohn’s disease,including its initial description,the research developments that happened in the years to follow,as well as the way it is regarded nowadays.It refers to notable contributions from medical figures,such as Dr.Crohn and his colleagues,examines related advances made in medical research and mentions the challenges and the treatment strategies that are still being discussed.Results:This article highlights the evolution of Crohn’s disease from a distinct condition to a more heterogeneous one.Furthermore,it refers to advancements made in medical research,such as the identification of CARD15(NOD2)gene mutations and the role of dysbiosis,and it examines current therapeutic approaches.Conclusion:Even though significant progress has been made since the initial description of Chron’s disease,there is no definitive cure,even though it has been determined that genetic and environmental factors are of great importance.The ongoing research could possibly lead to future discoveries and therefore aid in the discovery of efficient management and treatment of Crohn’s disease.展开更多
Diabetes mellitus is a group of metabolic diseases involving carbohydrate, lipid, and protein metabolism. It is characterized by persistent hyperglycemia which results from defects in insulin secretion, or action or b...Diabetes mellitus is a group of metabolic diseases involving carbohydrate, lipid, and protein metabolism. It is characterized by persistent hyperglycemia which results from defects in insulin secretion, or action or both. Diabetes mellitus has been known since antiquity. Descriptions have been found in the Egyptian papyri, in ancient Indian and Chinese medical literature, as well as, in the work of ancient Greek and Arab physicians. In the 2^(nd) century AD Aretaeus of Cappadocia provided the first accurate description of diabetes, coining the term diabetes, while in 17^(th) century Thomas Willis added the term mellitus to the disease, in an attempt to describe the extremely sweet taste of the urine. The important work of the 19^(th) century French physiologist Claude Bernard, on the glycogenic action of the liver, paved the way for further progress in the study of the disease. In 1889, Oskar Minkowski and Joseph von Mering performed their famous experiment of removing the pancreas from a dog and producing severe and fatal diabetes. In 1921, Frederick Banting and Charles Best extended Minkowski's and Mering's experiment. They isolated insulin from pancreatic islets and administrated to patients suffering from type 1 diabetes, saving thus the lives of millions and inaugurating a new era in diabetes treatment.展开更多
文摘Background:Crohn’s disease,described by Dr.Burrill Crohn and his colleagues in 1932,continues to be of great research and clinical interest.It was initially perceived as a distinct condition and it has evolved since into a complex disease,with debates still going regarding its classification and etiology.Even though more that 80 years of research have passed,numerous significant questions regarding the disease’s causes and best possible treatment strategies still remain.Methods:This article reviews both historical and contemporary perspectives on Crohn’s disease,including its initial description,the research developments that happened in the years to follow,as well as the way it is regarded nowadays.It refers to notable contributions from medical figures,such as Dr.Crohn and his colleagues,examines related advances made in medical research and mentions the challenges and the treatment strategies that are still being discussed.Results:This article highlights the evolution of Crohn’s disease from a distinct condition to a more heterogeneous one.Furthermore,it refers to advancements made in medical research,such as the identification of CARD15(NOD2)gene mutations and the role of dysbiosis,and it examines current therapeutic approaches.Conclusion:Even though significant progress has been made since the initial description of Chron’s disease,there is no definitive cure,even though it has been determined that genetic and environmental factors are of great importance.The ongoing research could possibly lead to future discoveries and therefore aid in the discovery of efficient management and treatment of Crohn’s disease.
文摘Diabetes mellitus is a group of metabolic diseases involving carbohydrate, lipid, and protein metabolism. It is characterized by persistent hyperglycemia which results from defects in insulin secretion, or action or both. Diabetes mellitus has been known since antiquity. Descriptions have been found in the Egyptian papyri, in ancient Indian and Chinese medical literature, as well as, in the work of ancient Greek and Arab physicians. In the 2^(nd) century AD Aretaeus of Cappadocia provided the first accurate description of diabetes, coining the term diabetes, while in 17^(th) century Thomas Willis added the term mellitus to the disease, in an attempt to describe the extremely sweet taste of the urine. The important work of the 19^(th) century French physiologist Claude Bernard, on the glycogenic action of the liver, paved the way for further progress in the study of the disease. In 1889, Oskar Minkowski and Joseph von Mering performed their famous experiment of removing the pancreas from a dog and producing severe and fatal diabetes. In 1921, Frederick Banting and Charles Best extended Minkowski's and Mering's experiment. They isolated insulin from pancreatic islets and administrated to patients suffering from type 1 diabetes, saving thus the lives of millions and inaugurating a new era in diabetes treatment.
