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易栓症筛查在青年卒中与TIA患者中的应用
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作者 VAFA ALAKBARZADE ALICE TAYLOR +1 位作者 marie scully 刘艳芳 《中国卒中杂志》 2019年第3期280-282,共3页
Stroke&Vascular Neurology(SVN)2018年发表的文章“Utility of current thrombophilia screening in young patients with stroke and TIA”,由来自英国伦敦大学医学院(University College London Hospital,UCLH)附属医院的国家医... Stroke&Vascular Neurology(SVN)2018年发表的文章“Utility of current thrombophilia screening in young patients with stroke and TIA”,由来自英国伦敦大学医学院(University College London Hospital,UCLH)附属医院的国家医疗服务体系(National Health Service,NHS)信托基金会Vafa Alakbarzade团队成员共同完成。 展开更多
关键词 TIA 青年卒中 易栓症 患者 筛查 医疗服务体系 附属医院 医学院
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Utility of current thrombophilia screening in young patients with stroke and TIA 被引量:3
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作者 Vafa Alakbarzade Alice Taylor +2 位作者 marie scully Robert Simister Arvind Chandratheva 《Stroke & Vascular Neurology》 SCIE 2018年第4期231-236,共6页
Introduction Approximately 40%of strokes in young adults are cryptogenic.The diagnostic yield of thrombophilia screening remains controversial.We aimed to determine utility of current thrombophilia testing for young p... Introduction Approximately 40%of strokes in young adults are cryptogenic.The diagnostic yield of thrombophilia screening remains controversial.We aimed to determine utility of current thrombophilia testing for young patients with stroke and transient ischaemic attack(TIA).Methods We present a retrospective review of all patients with stroke and TIA≤60 years presenting to University College London Hospital stroke unit and daily TIA clinic from 1 January 2015 to 1 August 2016.Consecutive clinical records and thrombophilia tests,including factor V Leiden(FVL),prothrombin G20210A mutation(PGM),antiphospholipid antibody(APA),and protein S,C and antithrombin(AT)levels,were reviewed.results The mean age of 628 patients with stroke and TIA was 49.1 years(SD 9.2).Thrombophilia testing was performed in 360(57%)patients,including 171 with stroke and 189 with TIA.Positive tests were found in 50(14%)patients,of whom 24 patients were<50 years.Positive results were found in 36(10%)with acute ischaemic stroke,4(1%)with haemorrhagic stroke and 10(3%)with TIA.Thirteen patients(4%)had homozygous/heterozygous FVL or PGM,and 27(7.5%)had positive APA(anticardiolipin antibody,anti-β2 glycoprotein antibody or lupus anticoagulant).Of 27(7.5%)patients with protein C,S or AT deficiency,10(2.8%)had primary deficiency,presumed hereditary with other secondary causes excluded.9%of patients with protein C,S or AT and 27%with APA were followed by confirmatory testing.Conclusion Thrombophilia testing was positive in only 14%of cases overall.Thrombophilia mutations and protein C,S or AT abnormalities were found rarely and were very uncommon in patients with TIA.Follow-up of abnormal results was generally poor for all groups,which further limited the impact of the thrombophilia testing policy. 展开更多
关键词 patients testing TIA
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