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Production and activity of matrix metalloproteinases during liver fibrosis progression of chronic hepatitis C patients 被引量:3
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作者 Moises Martinez-Castillo Abigail Hernandez-Barragan +10 位作者 Ivonne Flores-Vasconcelos marina galicia-moreno Dorothy Rosique-Oramas Jose Luis Perez-Hernandez Fatima Higuera-De la Tijera Eduardo E Montalvo-Jave Aldo Torre-Delgadillo Paula Cordero-Perez Linda Muñoz-Espinosa David Kershenobich Gabriela Gutierrez-Reyes 《World Journal of Hepatology》 2021年第2期218-232,共15页
BACKGROUND Matrix metalloproteinases(MMPs)participate in the degradation of extracellular matrix compounds,maintaining the homeostasis between fibrogenesis and fibrolytic processes in the liver.However,there are few s... BACKGROUND Matrix metalloproteinases(MMPs)participate in the degradation of extracellular matrix compounds,maintaining the homeostasis between fibrogenesis and fibrolytic processes in the liver.However,there are few studies on the regulation of liver MMPs in fibrosis progression in humans.AIM To assess the production activity and regulation of matrix metalloproteinases in liver fibrosis stages in chronic hepatitis C(CHC).METHODS A prospective,cross-sectional,multicenter study was conducted.CHC patients were categorized in fibrosis grades through FibroTest®and/or FibroScan®.Serum MMP-2,-7,and-9 were determined by western blot and multiplex suspension array assays.Differences were validated by the Kruskal-Wallis and Mann-Whitney U tests.The Spearman correlation coefficient and area under the receiver operating characteristic curve were calculated.Collagenolytic and gelatinase activity was determined through the Azocoll substrate and zymogram test,whereas tissue inhibitor of metalloproteinase-1 production was determined by dot blot assays.RESULTS Serum concentrations of the MMPs evaluated were higher in CHC patients than in healthy subjects.MMP-7 distinguished early and advanced stages,with a correlation of 0.32(P<0.001),and the area under the receiver operating characteristic displayed moderate sensitivity and specificity for MMP-7 in F4(area under the receiver operating characteristic,0.705;95%confidence interval:0.605-0.805;P<0.001).Collagenolytic activity was detected at F0 and F1,whereas gelatinase activity was not detected at any fibrosis stage.Tissue inhibitor of metalloproteinase-1 determination showed upregulation in F0 and F1 but downregulation in F2(P<0.001).CONCLUSION High concentrations of inactive MMPs were present in the serum of CHC patients,reflecting the impossibility to restrain liver fibrosis progression.MMPs could be good diagnostic candidates and therapeutic targets for improving novel strategies to reverse liver fibrosis in CHC. 展开更多
关键词 Extracellular matrix Matrix metalloproteinases Liver fibrosis Chronic hepatitis C FIBROGENESIS Fibrolysis
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Hepatocellular carcinoma and hepatitis C virus infection in Latin America: epidemiology, diagnosis and treatment
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作者 marina galicia-moreno Hugo Christian Monroy-Ramirez +3 位作者 marina Campos-Valdez Jaime Sanchez-Meza Laura Sanchez-Orozco Juan Armendariz-Borunda 《Hepatoma Research》 2020年第5期1-18,共18页
Hepatocellular carcinoma(HCC)is the most common cancer associated with chronic liver disease and cirrhosis.The most common cause of HCC is chronic hepatitis C virus infection and many studies in Europe,Asia and North ... Hepatocellular carcinoma(HCC)is the most common cancer associated with chronic liver disease and cirrhosis.The most common cause of HCC is chronic hepatitis C virus infection and many studies in Europe,Asia and North America have focused on its etiology,epidemiology,diagnostic tools,and therapeutic options.However,little is known about these issues in Latin America.The aim of this review is to address these aspects of HCC in Latin America.The main risk factors associated with developing HCC in this region are:age,concomitant cirrhosis,hepatitis C infection,obesity and hereditary disease such as hemochromatosis.On the other hand,screening tests and diagnostic methods of HCC are mostly serum alpha fetoprotein quantification,liver ultrasound,computed tomography,magnetic resonance,and histopathology.Novel diagnostic methods include gut microbiota analysis and the use of nanotechnology and they continue to be tested.Finally,according to the Barcelona Clinic Liver Cancer,curative treatments used in HCC patients are mainly liver resection,liver transplantation,and local ablation,each with advantages and disadvantages.In conclusion,clear strategies are urgently needed to understand the extent of HCC and related problems in this part of the world.This review provides greater knowledge of HCC for the proper design of preventive programs by taking into consideration specific characteristics of our population.Also,this review allows for an understanding of individualizing treatments according to the patient’s needs. 展开更多
关键词 LIVER hepatitis C EPIDEMIOLOGY DIAGNOSIS TREATMENT hepatocellular carcinoma Latin America
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