Bats are distinctive among mammals due to their ability to fly,use laryngeal echolocation,and tolerate viruses.However,there are currently no reliable cellular models for studying bat biology or their response to vira...Bats are distinctive among mammals due to their ability to fly,use laryngeal echolocation,and tolerate viruses.However,there are currently no reliable cellular models for studying bat biology or their response to viral infections.Here,we created induced pluripotent stem cells(iPSCs)from two species of bats:the wild greater horseshoe bat(Rhinolophus ferrumequinum)and the greater mouse-eared bat(Myotis myotis).The iPSCs from both bat species showed similar characteristics and had a gene expression profile resembling that of cells attacked by viruses.They also had a high number of endogenous viral sequences,particularly retroviruses.These results suggest that bats have evolved mechanisms to tolerate a large load of viral sequences and may have a more intertwined relationship with viruses than previously thought.Further study of bat iPSCs and their differentiated progeny will provide insights into bat biology,virus host relationships,and the molecular basis of bats'special traits.展开更多
Bats are distinctive among mammals due to their ability to fly, use laryngeal echolocation, and tolerate viruses. However,there are currently no reliable cellular models for studying bat biology or their response to v...Bats are distinctive among mammals due to their ability to fly, use laryngeal echolocation, and tolerate viruses. However,there are currently no reliable cellular models for studying bat biology or their response to viral infections. Here, we createdinduced pluripotent stem cells (iPSCs) from two species of bats: the wild greater horseshoe bat (Rhinolophus ferrumequinum) andthe greater mouse-eared bat (Myotis myotis). The iPSCs from both bat species showed similar characteristics and had a geneexpression profile resembling that of cells attacked by viruses. They also had a high number of endogenous viral sequences,particularly retroviruses. These results suggest that bats have evolved mechanisms to tolerate a large load of viral sequences andmay have a more intertwined relationship with viruses than previously thought. Further study of bat iPSCs and their differentiatedprogeny will provide insights into bat biology, virus host relationships, and the molecular basis of bats' special traits.展开更多
文摘Bats are distinctive among mammals due to their ability to fly,use laryngeal echolocation,and tolerate viruses.However,there are currently no reliable cellular models for studying bat biology or their response to viral infections.Here,we created induced pluripotent stem cells(iPSCs)from two species of bats:the wild greater horseshoe bat(Rhinolophus ferrumequinum)and the greater mouse-eared bat(Myotis myotis).The iPSCs from both bat species showed similar characteristics and had a gene expression profile resembling that of cells attacked by viruses.They also had a high number of endogenous viral sequences,particularly retroviruses.These results suggest that bats have evolved mechanisms to tolerate a large load of viral sequences and may have a more intertwined relationship with viruses than previously thought.Further study of bat iPSCs and their differentiated progeny will provide insights into bat biology,virus host relationships,and the molecular basis of bats'special traits.
文摘Bats are distinctive among mammals due to their ability to fly, use laryngeal echolocation, and tolerate viruses. However,there are currently no reliable cellular models for studying bat biology or their response to viral infections. Here, we createdinduced pluripotent stem cells (iPSCs) from two species of bats: the wild greater horseshoe bat (Rhinolophus ferrumequinum) andthe greater mouse-eared bat (Myotis myotis). The iPSCs from both bat species showed similar characteristics and had a geneexpression profile resembling that of cells attacked by viruses. They also had a high number of endogenous viral sequences,particularly retroviruses. These results suggest that bats have evolved mechanisms to tolerate a large load of viral sequences andmay have a more intertwined relationship with viruses than previously thought. Further study of bat iPSCs and their differentiatedprogeny will provide insights into bat biology, virus host relationships, and the molecular basis of bats' special traits.
