Combined low-dose radon/hyperthermia therapy has been reported to improve pain and mobility in patients with rheumatic disorders. The key feature of inflammatory rheumatic diseases is the induction of autoimmune proce...Combined low-dose radon/hyperthermia therapy has been reported to improve pain and mobility in patients with rheumatic disorders. The key feature of inflammatory rheumatic diseases is the induction of autoimmune processes via the production of autoantibodies. As reducing the autoantibody level through administration of biologicals is described to correlate with delay of disease progression, we investigated the impact of combined low-dose radon/hyperthermia therapy on the serum levels of antibodies directed against cyclic citrullinated peptides in patients with ankylosing spondylitis. We found that levels of circulating anti-CCP antibodies is significantly reduced immediately after a 3 weeks of radon therapy regimen.展开更多
Management of biliary tract cancer remains challenging. Tumors show high recurrence rates and therapeutic resistance, leading to dismal prognosis and short survival. The cancer stem cell model states that a tumor is a...Management of biliary tract cancer remains challenging. Tumors show high recurrence rates and therapeutic resistance, leading to dismal prognosis and short survival. The cancer stem cell model states that a tumor is a heterogeneous conglomerate of cells, in which a certain subpopulation of cells-the cancer stem cells-possesses stem cell properties. Cancer stem cells have high clinical relevance due to their potential contributions to development, progression and aggressiveness as well as recurrence and metastasis of malignant tumors. Consequently, reliable identification of as well as pharmacological intervention with cancer stem cells is an intensively investigated and promising research field. The involvement of cancer stem cells in biliary tract cancer is likely as a number of studies demonstrated their existence and the obvious clinical relevance of several established cancer stem cell markers in biliary tract cancer models and tissues. In the present article, we review and discuss the currently available literature addressing the role of putative cancer stem cells in biliary tract cancer as well as the connection between known contributors of biliary tract tumorigenesis such as oncogenic signaling pathways, micro-RNAs and the tumor microenvironment with cancer stem cells.展开更多
Durante il mese di agosto 1993 si è osservata ripetutamente una coppia adulta,con quattro giovani già volanti,di Rondine rossiccia Hirundo daurica nel comunedi Gargnano (tav.IGMI 35 Ⅲ SE,Gargnano).Le osserv...Durante il mese di agosto 1993 si è osservata ripetutamente una coppia adulta,con quattro giovani già volanti,di Rondine rossiccia Hirundo daurica nel comunedi Gargnano (tav.IGMI 35 Ⅲ SE,Gargnano).Le osservazioni si sono protratte dal 18 al 27 agosto,in un oliveto coltivato,esposto a SE e situato tra la via Prea e la strada statale 45 bis《Gardesana occidenta-le》,a circa 150 m s.l.m.I giovani erano già in grado di cacciare insetti in volo,ma ritornavano spesso al posatoio abituale costituito da un tratto di cavo telefonicoattraversante l’oliveto,dove venivano ancora imbeccati dai genitori.Durante il展开更多
文摘Combined low-dose radon/hyperthermia therapy has been reported to improve pain and mobility in patients with rheumatic disorders. The key feature of inflammatory rheumatic diseases is the induction of autoimmune processes via the production of autoantibodies. As reducing the autoantibody level through administration of biologicals is described to correlate with delay of disease progression, we investigated the impact of combined low-dose radon/hyperthermia therapy on the serum levels of antibodies directed against cyclic citrullinated peptides in patients with ankylosing spondylitis. We found that levels of circulating anti-CCP antibodies is significantly reduced immediately after a 3 weeks of radon therapy regimen.
基金Supported by Studies of the authors Mayr C,Pichler M,Neureiter D and Kiesslich T in the research field of this review were supported by research grants of the Jubilaumsfonds derosterreichischen Nationalbank,No.12677 and No.14842the research fund of the Paracelsus Medical University Salzburg,No.08/07/037,No.A-12/02/006-KIE and No.R-16/03/083-MAY
文摘Management of biliary tract cancer remains challenging. Tumors show high recurrence rates and therapeutic resistance, leading to dismal prognosis and short survival. The cancer stem cell model states that a tumor is a heterogeneous conglomerate of cells, in which a certain subpopulation of cells-the cancer stem cells-possesses stem cell properties. Cancer stem cells have high clinical relevance due to their potential contributions to development, progression and aggressiveness as well as recurrence and metastasis of malignant tumors. Consequently, reliable identification of as well as pharmacological intervention with cancer stem cells is an intensively investigated and promising research field. The involvement of cancer stem cells in biliary tract cancer is likely as a number of studies demonstrated their existence and the obvious clinical relevance of several established cancer stem cell markers in biliary tract cancer models and tissues. In the present article, we review and discuss the currently available literature addressing the role of putative cancer stem cells in biliary tract cancer as well as the connection between known contributors of biliary tract tumorigenesis such as oncogenic signaling pathways, micro-RNAs and the tumor microenvironment with cancer stem cells.
文摘Durante il mese di agosto 1993 si è osservata ripetutamente una coppia adulta,con quattro giovani già volanti,di Rondine rossiccia Hirundo daurica nel comunedi Gargnano (tav.IGMI 35 Ⅲ SE,Gargnano).Le osservazioni si sono protratte dal 18 al 27 agosto,in un oliveto coltivato,esposto a SE e situato tra la via Prea e la strada statale 45 bis《Gardesana occidenta-le》,a circa 150 m s.l.m.I giovani erano già in grado di cacciare insetti in volo,ma ritornavano spesso al posatoio abituale costituito da un tratto di cavo telefonicoattraversante l’oliveto,dove venivano ancora imbeccati dai genitori.Durante il
