Peripheral nerve injury leads to Wallerian degeneration of severed axons,leaving the Schwann cell（SC）sheath behind.Denervated SCs may then either survive and remyelinate a regenerating axon,or they may undergo cell ...Peripheral nerve injury leads to Wallerian degeneration of severed axons,leaving the Schwann cell（SC）sheath behind.Denervated SCs may then either survive and remyelinate a regenerating axon,or they may undergo cell death.Because SCs provide trophic support and guidance cues to regenerating nerve fibers,SC loss severely hampers nerve regeneration（Hall,1986）.展开更多
文摘Peripheral nerve injury leads to Wallerian degeneration of severed axons,leaving the Schwann cell（SC）sheath behind.Denervated SCs may then either survive and remyelinate a regenerating axon,or they may undergo cell death.Because SCs provide trophic support and guidance cues to regenerating nerve fibers,SC loss severely hampers nerve regeneration（Hall,1986）.
