Efficient cellular fusion of mononuclear precursors is the prerequisite for the generation of fully functional multinucleated bone-resorbing osteoclasts.However,the exact molecular factors and mechanisms controlling o...Efficient cellular fusion of mononuclear precursors is the prerequisite for the generation of fully functional multinucleated bone-resorbing osteoclasts.However,the exact molecular factors and mechanisms controlling osteoclast fusion remain incompletely understood.Here we identify RANKL-mediated activation of caspase-8 as early key event during osteoclast fusion.展开更多
We give a survey of results on the construction of and obstructions to metrics of almost nonnegative curvature operator on closed manifolds and results on the cohomology rings of closed, simply-connected manifolds wit...We give a survey of results on the construction of and obstructions to metrics of almost nonnegative curvature operator on closed manifolds and results on the cohomology rings of closed, simply-connected manifolds with a lower curvature and upper diameter bound. The latter is motivated by a question of Grove whether these condition imply finiteness of rational homotopy types. This question has answers by F. Fang-X. Rong, B. Totaro and recently A. Dessai and the present author.展开更多
All biological systems rely on regulatory networks of positive and negative feedback that enable targeted and rapid adaptations,while negative autosignals limit overstimulation and enable self-shutdown.A recent public...All biological systems rely on regulatory networks of positive and negative feedback that enable targeted and rapid adaptations,while negative autosignals limit overstimulation and enable self-shutdown.A recent publication in Science^(1) demonstrates a shutdown mechanism in neutrophils that limits their aggregation dynamics while enhancing bacterial killing.^(1)展开更多
基金supported by the Bayerische Forschungsstiftung to B.K.the Deutsche Forschungsgemeinschaft (CRC1181 to G.K.and G.S.+3 种基金SCHE 2062/1-1 to C.S.)funded by the Wellcome Trust Investigator Award (107964/Z/15/Z)the UK Dementia Research Institutefunded by BBSRC Discovery Fellowship (BB/T009543/1)。
文摘Efficient cellular fusion of mononuclear precursors is the prerequisite for the generation of fully functional multinucleated bone-resorbing osteoclasts.However,the exact molecular factors and mechanisms controlling osteoclast fusion remain incompletely understood.Here we identify RANKL-mediated activation of caspase-8 as early key event during osteoclast fusion.
文摘We give a survey of results on the construction of and obstructions to metrics of almost nonnegative curvature operator on closed manifolds and results on the cohomology rings of closed, simply-connected manifolds with a lower curvature and upper diameter bound. The latter is motivated by a question of Grove whether these condition imply finiteness of rational homotopy types. This question has answers by F. Fang-X. Rong, B. Totaro and recently A. Dessai and the present author.
文摘All biological systems rely on regulatory networks of positive and negative feedback that enable targeted and rapid adaptations,while negative autosignals limit overstimulation and enable self-shutdown.A recent publication in Science^(1) demonstrates a shutdown mechanism in neutrophils that limits their aggregation dynamics while enhancing bacterial killing.^(1)
