Globally,millions of people die of microbial infection-related diseases every year.The more terrible situation is that due to the overuse of antibiotics,especially in developing countries,people are struggling to figh...Globally,millions of people die of microbial infection-related diseases every year.The more terrible situation is that due to the overuse of antibiotics,especially in developing countries,people are struggling to fight with the bacteria variation.The emergence of super-bacteria will be an intractable environmental and health hazard in the future unless novel bactericidal weapons are mounted.Consequently,it is critical to develop viable antibacterial approaches to sustain the prosperous development of human society.Recent researches indicate that transition metal sulfides(TMSs)represent prominent bactericidal application potential owing to the meritorious antibacterial performance,acceptable biocompatibility,high solar energy utilization efficiency,and excellent photo-to-thermal conversion characteristics,and thus,a comprehensive review on the recent advances in this area would be beneficial for the future development.In this review article,we start with the antibacterial mechanisms of TMSs to provide a preliminary understanding.Thereafter,the state-of-the-art research progresses on the strategies for TMSs materials engineering so as to promote their antibacterial properties are systematically surveyed and summarized,followed by a summary of the practical application scenarios of TMSs-based antibacterial platforms.Finally,based on the thorough survey and analysis,we emphasize the challenges and future development trends in this area.展开更多
Exosomes have been recognized as extracellular vesicles that mediate systemic information exchange and long-distance interactions between cells.1 Their functions are all highly reliant on systemic biological distribut...Exosomes have been recognized as extracellular vesicles that mediate systemic information exchange and long-distance interactions between cells.1 Their functions are all highly reliant on systemic biological distribution so that it is possible to promote the biological effects for therapy by accurately manipulating exosome biodistribution.However,given that the mechanisms for regulating the exosome biodistribution are unclear,it is challengeable to achieve the manipulation of exosome biodistribution by regulating molecular signals.Recently,Liu et al.2 reported a vesicle shuttle(VS),which was composed of a ferroferric oxide core,a silica shell,and a stimuli-cleavable poly(ethylene glycol)corona conjugated to two types of antibody(one against antigens on the exosomes of interest,and the other targeted to the recipient injured cells).2 They showed that the VS could effectively collect,transport,and release circulating exosomes to the designated areas inside the organism.展开更多
基金supported by the National Natural Science Foundation of China(Nos.21902085 and 51572157)the Natural Science Foundation of Shandong Province(Nos.ZR2019QF012 and ZR2019BEM024)+7 种基金Shenzhen Fundamental Research Program(Nos.JCYJ20190807093205660 and JCYJ20190807092803583)the Natural Science Foundation of Jiangsu Province(No.BK20190205)the Guangdong Basic and Applied Basic Research Foundation(No.2019A1515110846)the Fundamental Research Funds for the Central Universities(Nos.2018JC046 and 2018JC047)Medical and Health Science and Technology Development Project of Shandong Province(No.2018WSA01018)Science Development Program Project of Jinan(No.201805048)the Deans Research Assistance Foundation of Ji Nan Stomatology Hospital(2018-02)the Qilu Young Scholar Program of Shandong University(Nos.31370088963043 and 31370088963056).
文摘Globally,millions of people die of microbial infection-related diseases every year.The more terrible situation is that due to the overuse of antibiotics,especially in developing countries,people are struggling to fight with the bacteria variation.The emergence of super-bacteria will be an intractable environmental and health hazard in the future unless novel bactericidal weapons are mounted.Consequently,it is critical to develop viable antibacterial approaches to sustain the prosperous development of human society.Recent researches indicate that transition metal sulfides(TMSs)represent prominent bactericidal application potential owing to the meritorious antibacterial performance,acceptable biocompatibility,high solar energy utilization efficiency,and excellent photo-to-thermal conversion characteristics,and thus,a comprehensive review on the recent advances in this area would be beneficial for the future development.In this review article,we start with the antibacterial mechanisms of TMSs to provide a preliminary understanding.Thereafter,the state-of-the-art research progresses on the strategies for TMSs materials engineering so as to promote their antibacterial properties are systematically surveyed and summarized,followed by a summary of the practical application scenarios of TMSs-based antibacterial platforms.Finally,based on the thorough survey and analysis,we emphasize the challenges and future development trends in this area.
文摘Exosomes have been recognized as extracellular vesicles that mediate systemic information exchange and long-distance interactions between cells.1 Their functions are all highly reliant on systemic biological distribution so that it is possible to promote the biological effects for therapy by accurately manipulating exosome biodistribution.However,given that the mechanisms for regulating the exosome biodistribution are unclear,it is challengeable to achieve the manipulation of exosome biodistribution by regulating molecular signals.Recently,Liu et al.2 reported a vesicle shuttle(VS),which was composed of a ferroferric oxide core,a silica shell,and a stimuli-cleavable poly(ethylene glycol)corona conjugated to two types of antibody(one against antigens on the exosomes of interest,and the other targeted to the recipient injured cells).2 They showed that the VS could effectively collect,transport,and release circulating exosomes to the designated areas inside the organism.