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Non-albicans candidemia in cancer patients as an increasing health problem:A comprehensive review and meta-analysis
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作者 Aynaz Ghojoghi maryam erfaninejad +3 位作者 Ehsan Ahmadpour Eisa Nazar Aleksandra Barac Mahnaz Fatahinia 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2022年第9期387-399,共13页
Objective:To evaluate the prevalence of Candida species in cancer patients with candidemia around the world,and to identify related risk factors and their antifungal resistance,with an emphasis on non-albicans Candida... Objective:To evaluate the prevalence of Candida species in cancer patients with candidemia around the world,and to identify related risk factors and their antifungal resistance,with an emphasis on non-albicans Candida species(NACs).Methods:The published papers related to the subject were systematically searched in databases of MEDLINE(including PubMed),Web of Science,Scopus,Science Direct,and Google Scholar between the 1st January 2000 and 21st April 2021.Results:Among the 4546 records,69 studies met the inclusion criteria.The pooled prevalence of NACs in cancer patients with candidemia was 62%(95%CI 58%-67%;I2=94.85%,P=0.00).Based on type of cancer,the pooled prevalence of NACs in hematologic and solid cancer patients were 68%(95%CI 65%-70%)and 52%(95%CI 49%-54%),respectively.Among NACs,Candida(C.)parapsilosis was the most frequently isolated organism followed by C.tropicalis and C.glabrata.In addition,the therapeutic usage of antibiotics was found as the most common risk factor,accounting for 85%(95%CI 81%-89%)and central venous catheter accounting for 69%(95%CI 62%-77%).Conclusions:The incidence of Candida bloodstream infections among cancer patients is a growing concern,especially when the etiologic agents of candidemia tend to shift towards NACs. 展开更多
关键词 CANDIDEMIA Non-albicans Candida Cancer EPIDEMIOLOGY Systematic review META-ANALYSIS
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