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Epidemiology of co-infections in pregnant women living with human immunodeficiency virus 1 in rural Gabon:a cross-sectional study
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作者 Saskia Dede Davi Dearie Glory Okwu +10 位作者 Marc Luetgehetmann Frederique Mbang Abba Martin Aepfelbacher Lillian Rene Endamne Ayodele Alabi Rella Zoleko-Manego Ghyslain Mombo-Ngoma Saidou Mahmoudou marylyn martina addo Michael Ramharter Johannes Mischlinger 《Infectious Diseases of Poverty》 SCIE CAS CSCD 2023年第4期83-92,共10页
Background There is no recent epidemiological data on HIV infection in Gabon,particularly in pregnant women.To close this gap,an HIV-prevalence survey was conducted among Gabonese pregnant women,followed by a cross-se... Background There is no recent epidemiological data on HIV infection in Gabon,particularly in pregnant women.To close this gap,an HIV-prevalence survey was conducted among Gabonese pregnant women,followed by a cross-sectional case-control study in which the prevalence of various co-infections was compared between HIV-positive and HIV-negative pregnant women.Methods Between 2018 and 2019,data for the HIV-prevalence survey were collected retrospectively in 21 Gabonese antenatal care centres(ANCs).Subsequently,for the prospective co-infection study,all HIV-positive pregnant women were recruited who frequented the ANC in Lambarénéand a comparator sub-sample of HIV-negative pregnant women was recruited;these activities were performed from February 2019 to February 2020.The mean number of coinfections was ascertained and compared between HIV-positive and HIV-negative women.Additionally,the odds for being co-infected with at least one co-infection was evaluated and compared between HIV-positive and HIV-negative women.Results HIV-positivity was 3.9%(646/16,417)among pregnant women.183 pregnant women were recruited in the co-infection study.63%of HIV-positive and 75%of HIV-negative pregnant women had at least one co-infection.There was a trend indicating that HIV-negative women were more often co-infected with sexually transmitted infections(STIs)than HIV-positive women[mean(standard deviation,SD):2.59(1.04)vs 2.16(1.35),respectively;P=0.056];this was not the case for vector-borne infections[mean(SD):0.47(0.72)vs 0.43(0.63),respectively;P=0.59].Conclusions Counterintuitively,the crude odds for concomitant STIs was lower in HIV-positive than in HIV-negative women.The change of magnitude from the crude to adjustedOR is indicative for a differential sexual risk factor profile among HIV-positive and HIV-negative women in this population.This might potentially be explained by the availability of sexual health care counselling for HIV-positive women within the framework of the national HIV control programme,while no such similar overall service exists for HIV-negative women.This highlights the importance of easy access to sexual healthcare education programmes for all pregnant women irrespective of HIV status. 展开更多
关键词 HIV Cross-sectional study PREGNANCY Sexually transmitted infections GABON
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