With the increasing application of regenerative medicine in vivo,non-invasive and accurate methods for estimating the white matter axons in neuronal tissue have become increasingly important.As a non-invasive method f...With the increasing application of regenerative medicine in vivo,non-invasive and accurate methods for estimating the white matter axons in neuronal tissue have become increasingly important.As a non-invasive method for patients,magnetic resonance（MR）imaging has demonstrated potential as a promising tool for evaluating axons in vivo.In particular,diffusion-weighted MR imaging（d MRI）and its applications,展开更多
Diffusion tensor tractography was used to evaluate whether diffusion metrics in the nigrostriatal pathway could diagnose Parkinson disease. Diffusion tensor imaging was performed on 30 patients with Parkinson disease ...Diffusion tensor tractography was used to evaluate whether diffusion metrics in the nigrostriatal pathway could diagnose Parkinson disease. Diffusion tensor imaging was performed on 30 patients with Parkinson disease and 32 healthy controls by using a 3.0 Tesla magnetic resonance imaging system. Diffusion tensor tractography was used for both groups to visualize the nigrostriatal and corticospinal tracts. The fractional anisotropy (FA) and mean diffusivity (MD) of the tracts were evaluated. Receiver operating characteristic (ROC) analysis was used to determine whether diffusion metrics of the nigrostriatal pathway could be used to diagnose Parkinson disease. Mean FA values (±SD) of the nigrostriatal tract in Parkinson disease patients (0.41 ± 0.025) were significantly lower than those in the control group (0.43 ± 0.022;p = 0.00068) and showed a sensitivity of 66.7% and specificity of 60%. There were no significant differences in the MD values of the nigrostriatal tract or the FA and MD values of the corticospinal tract between Parkinson disease patients and the control group. FA values of the nigrostriatal pathway in Parkinson disease patients were significantly lower than those in normal, healthy individuals. Reduced FA was generally thought to reflect neuronal loss, gliosis, or demyelination of nerve fibers. This result might provide a useful measure for diagnosing Parkinson disease and evaluating patients’ clinical condition.展开更多
基金supported by JSPS KAKENHI Grant Number JP16H06280Grant-in-Aid for Scientific Research on Innovative Areas-Resource and technical support platforms for promoting research‘Advanced Bioimaging Support’the Im PACT Program of Council for Science,Technology and Innovation(Cabinet Office,Government of Japan)
文摘With the increasing application of regenerative medicine in vivo,non-invasive and accurate methods for estimating the white matter axons in neuronal tissue have become increasingly important.As a non-invasive method for patients,magnetic resonance（MR）imaging has demonstrated potential as a promising tool for evaluating axons in vivo.In particular,diffusion-weighted MR imaging（d MRI）and its applications,
文摘Diffusion tensor tractography was used to evaluate whether diffusion metrics in the nigrostriatal pathway could diagnose Parkinson disease. Diffusion tensor imaging was performed on 30 patients with Parkinson disease and 32 healthy controls by using a 3.0 Tesla magnetic resonance imaging system. Diffusion tensor tractography was used for both groups to visualize the nigrostriatal and corticospinal tracts. The fractional anisotropy (FA) and mean diffusivity (MD) of the tracts were evaluated. Receiver operating characteristic (ROC) analysis was used to determine whether diffusion metrics of the nigrostriatal pathway could be used to diagnose Parkinson disease. Mean FA values (±SD) of the nigrostriatal tract in Parkinson disease patients (0.41 ± 0.025) were significantly lower than those in the control group (0.43 ± 0.022;p = 0.00068) and showed a sensitivity of 66.7% and specificity of 60%. There were no significant differences in the MD values of the nigrostriatal tract or the FA and MD values of the corticospinal tract between Parkinson disease patients and the control group. FA values of the nigrostriatal pathway in Parkinson disease patients were significantly lower than those in normal, healthy individuals. Reduced FA was generally thought to reflect neuronal loss, gliosis, or demyelination of nerve fibers. This result might provide a useful measure for diagnosing Parkinson disease and evaluating patients’ clinical condition.
