剪切应力对骨髓间充质干细胞迁移的影响及相关分子机理研究

引言骨髓间充质干细胞(Bone marrow-derived mesenchymal stem cells,BMSC)具有归巢、迁移至组织受损部位并参与修复的特性。当机体发生损伤时,骨髓中的BMSC感知损伤信号移出骨髓进入外周血循环,与靶组织血管内皮细胞相互作用并穿过胞外基质屏障,然后到达损伤部位参与组织修复和重建。通过外周血循环的迁移过程是自体动员和人工移植BMSC抵达损伤部位、参与损伤组织修复的重要环节。BMSC在此迁移过程中不仅受血液中化学因素的调控,同时还受到血液流动产生的流体剪切应力的影响。目前,人们对流体剪切应力影响BMSC迁移行为的生物学规律及分子机理还缺乏系统认识。本文主要考察不同大小剪切应力对BMSC迁移能力的影响及相关分子基础。

Chronic lung allograft dysfunction post-lung transplantation:The era of bronchiolitis obliterans syndrome and restrictive allograft syndrome

Chronic lung allograft dysfunction(CLAD)following lung transplantation limits long-term survival considerably.The main reason for this is a lack of knowledge regarding the pathological condition and the establishment of treatment.The consensus statement from the International Society for Heart and Lung Transplantation on CLAD in 2019 classified CLAD into two main phenotypes:Bronchiolitis obliterans syndrome and restrictive allograft syndrome.Along with this clear classification,further exploration of the mechanisms and the development of appropriate prevention and treatment strategies for each phenotype are desired.In this review,we summarize the new definition of CLAD and update and summarize the existing knowledge on the underlying mechanisms of bronchiolitis obliterans syndrome and restrictive allograft syndrome,which have been elucidated from clinicopathological observations and animal experiments worldwide.