期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
CD34+ dermal dendritic cells and mucin deposition in dermatomyositis
1
作者 Emi Yokoyama Yoshitaka Nakamura +2 位作者 Tomoko Okita Nobuyuki Nagai masahiko muto 《World Journal of Dermatology》 2016年第2期65-71,共7页
Dermal mucinosis is often associated with collagen diseases such as rheumatoid arthritis, lupus erythematosus, and dermatomyositis, in addition to autoimmune thyroiditis. We report eight cases of dermal mucin depositi... Dermal mucinosis is often associated with collagen diseases such as rheumatoid arthritis, lupus erythematosus, and dermatomyositis, in addition to autoimmune thyroiditis. We report eight cases of dermal mucin deposition secondary to typical dermatomyositis with cutaneous lesions known as heliotrope rash and Gottron's papules. Striking mucin deposition was observed in both the papillary dermis and reticular dermis of all biopsy specimens. Immunohistochemical analysis showed that CD34+ dermal dendritic cells(DDCs) in the perilesional area in combination with vimentin+ cells within the mucinous lesion might be important in giving rise to abnormal deposition of dermal mucin. On the other hand, numbers of factor ⅩⅢa+ DDCs and tryptase+ mast cells were reduced within and surrounding the mucin deposition, as compared with those in the dermis of normal controls. A pathogenic mechanism of dermal mucin deposition is proposed. 展开更多
关键词 MUCIN deposition DERMATOMYOSITIS CD34+dermal DENDRITIC cell
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部