INTRODUCTION The Mongolian gerbil(Meriones unguiculatus)has been used as an animal model for pharmacology(Wu et al.2008),parasitology(Lim et al.2004),and studies of reproduction(Kai et al.1995).The molecular mechanism...INTRODUCTION The Mongolian gerbil(Meriones unguiculatus)has been used as an animal model for pharmacology(Wu et al.2008),parasitology(Lim et al.2004),and studies of reproduction(Kai et al.1995).The molecular mechanisms of several coat-color phenotypes are known in gerbils(Petrij et al.2001,2007).On the other hand,although albinism in gerbils was first reported by Matsuzaki et al.(1989),its molecular mechanism is still unclear.In a previous study,we reported the establishment of the albino gerbil strain(strain code:MON/Num/c)as a closed colony and the agouti-colored strain(strain code:MON/Num/a)as inbred.Our albino strain had 4 nucleotide substitutions and 2 missense mutations(R77H in exon 1 and Q473R in exon 5)in the tyrosinase(Tyr)gene(Ukaji et al.2016).展开更多
文摘INTRODUCTION The Mongolian gerbil(Meriones unguiculatus)has been used as an animal model for pharmacology(Wu et al.2008),parasitology(Lim et al.2004),and studies of reproduction(Kai et al.1995).The molecular mechanisms of several coat-color phenotypes are known in gerbils(Petrij et al.2001,2007).On the other hand,although albinism in gerbils was first reported by Matsuzaki et al.(1989),its molecular mechanism is still unclear.In a previous study,we reported the establishment of the albino gerbil strain(strain code:MON/Num/c)as a closed colony and the agouti-colored strain(strain code:MON/Num/a)as inbred.Our albino strain had 4 nucleotide substitutions and 2 missense mutations(R77H in exon 1 and Q473R in exon 5)in the tyrosinase(Tyr)gene(Ukaji et al.2016).
