In anticipation of the massive burden of neurodegenerative disease within super-aged societies, great efforts have been made to utilize neural stem and progenitor cells for regenerative medicine. The capacity of intri...In anticipation of the massive burden of neurodegenerative disease within super-aged societies, great efforts have been made to utilize neural stem and progenitor cells for regenerative medicine. The capacity of intrinsic neural stem and progenitor cells to regenerate damaged brain tissue remains unclear, due in part to the lack of knowledge about how these newly born neurons integrate into functional circuitry. As sizable integration of adult-born neurons naturally occurs in the dentate gyrus region of the hippocampus, clarifying the mechanisms of this process could provide insights for applying neural stem and progenitor cells in clinical settings. There is convincing evidence of functional correlations between adult-born neurons and memory consolidation and sleep; therefore, we describe some new advances that were left untouched in our recent review.展开更多
Introduction: Memory consolidation stabilizes newly acquired memories by integrating them into pre-existing memory networks, which is thought to occurvia changes in synaptic strength. Sleep may influence memory consol...Introduction: Memory consolidation stabilizes newly acquired memories by integrating them into pre-existing memory networks, which is thought to occurvia changes in synaptic strength. Sleep may influence memory consolidation by modifying synaptic strength through local neuronal oscillatory activity.展开更多
基金partially supported by the MEXT World Premier International Research Center Initiative,CREST JST,MEXT KAKENHI for Scientific Research on Innovative Areas "Microendophenotype"(25116530)and "Memory Dynamism"(26115502)JSPS KAKENHI Grants(16K18359,15F15408)+12 种基金Research Foundation for Opto-Science and TechnologyKato Memorial Bioscience FoundationJapan Foundation for Applied EnzymologyUehara Memorial Foundation2016 Inamori Research Grants ProgramIchiro Kanehara Foundation for the Promotion of Medical Sciences and Medical CareLife Science Foundation of JapanKowa Life Science Foundation Research GrantGSK Japan Research GrantKANAE Foundation for the Promotion of Medical ScienceShimadzu Foundation for the Promotion of Science and TechnologyTakeda Science Foundation to MSThe Tokyo Biochemical Research Foundation to SS
文摘In anticipation of the massive burden of neurodegenerative disease within super-aged societies, great efforts have been made to utilize neural stem and progenitor cells for regenerative medicine. The capacity of intrinsic neural stem and progenitor cells to regenerate damaged brain tissue remains unclear, due in part to the lack of knowledge about how these newly born neurons integrate into functional circuitry. As sizable integration of adult-born neurons naturally occurs in the dentate gyrus region of the hippocampus, clarifying the mechanisms of this process could provide insights for applying neural stem and progenitor cells in clinical settings. There is convincing evidence of functional correlations between adult-born neurons and memory consolidation and sleep; therefore, we describe some new advances that were left untouched in our recent review.
基金partially supported by grants from the World Premier International Research Center Initiative from MEXT,JST CREST grant#JPMJCR1655,JSPS KAKENHI grants#16K18359,15F15408,15H01276,15K18332,26115502,25116530,JP16H06280,and 20H03552Takeda Science Foundation+12 种基金Shimadzu Science FoundationKanae FoundationResearch Foundation for Opto-Science and TechnologyIchiro Kanehara FoundationKato Memorial Bioscience FoundationJapan Foundation for Applied EnzymologySenshin Medical Research FoundationLife Science Foundation of JapanUehara Memorial FoundationBrain Science FoundationKowa Life Science FoundationInamori Research Grants ProgramGSK Japan to MS。
文摘Introduction: Memory consolidation stabilizes newly acquired memories by integrating them into pre-existing memory networks, which is thought to occurvia changes in synaptic strength. Sleep may influence memory consolidation by modifying synaptic strength through local neuronal oscillatory activity.
