Superior vena cava syndrome (SVCS) patients sometimes show signs of obstructive sleep apnea (OSA). However, the mechanism causing hypoxia during sleep in SVCS patients is still uncertain. The aim of this study was to ...Superior vena cava syndrome (SVCS) patients sometimes show signs of obstructive sleep apnea (OSA). However, the mechanism causing hypoxia during sleep in SVCS patients is still uncertain. The aim of this study was to elucidate 1) the changes in central and peripheral respiratory resistance with SVCS, and 2) interpret the mechanism underlying the development of hypoxia during sleep in patients with SVCS related to OSA. Ten SVCS patients related to a neoplasm were recruited for this study. The degree of apnea hypopnea index (AHI) for OSA was evaluated by portable diagnosing device before and after SVCS treatment. We also analyzed the airway resistance and reactance quantitatively in the supine position by Master Screen impulse oscillometry system (MS-IOS?). After SVCS treatment, mean values of AHI were significantly decreased from 30.9 to 16.9 (/hour) (p = 0.001). Central respiratory resistance (R20) also decreased significantly from 0.40 to 0.33 kPa/L/s (p = 0.025) in the supine position. In contrast, peripheral respiratory resistance (R5-R20) and distal capacitive reactance (X5) did not change significantly. It is thought that the exacerbation of OSA due to SVCS is caused by increasing upper airway resistance related to reversible edema of the upper airway mucous or tissue. In contrast, SVCS may not cause peripheral respiratory tract and lung parenchyma edema.展开更多
We report here a case of a patient who underwent surgical resection of a giant pericardial cyst that was growing rapidly, causing anterior chest pain. An asymptomatic 56-year-old woman underwent a complete medical che...We report here a case of a patient who underwent surgical resection of a giant pericardial cyst that was growing rapidly, causing anterior chest pain. An asymptomatic 56-year-old woman underwent a complete medical checkup in a health-care center. Her chest X-ray showed an unusually large bulge on the left cardiac border, and she was referred to our hospital. The chest X-ray taken 2 years ago in another hospital showed similar bulge on the same left cardiac border, but it was noticeably smaller. Chest CT revealed a 9.5 × 4.5 cm pericardial cyst within the anterolateral aspect of the left cardiac border. The CT number of the mass was approximately 15 - 20 HU. The mass also showed slight hyperintensity on T1-weighted MR images and hyperintensity on T2-weighted MR images. Four weeks later, she experienced anterior chest pain for the first time, and the chest X-ray and CT showed an increase in the size of the pericardial cyst. The CT number of the mass increased to approximately 30 - 40 HU. The cyst was successfully removed by video-assisted thoracic surgery. The pericardial cyst was diagnosed as benign according to the results of histopathology. We conclude that the rapid growth of the pericardial cyst was caused by intracystic hemorrhage that originated from vascularized connective tissue in the cyst wall.展开更多
文摘Superior vena cava syndrome (SVCS) patients sometimes show signs of obstructive sleep apnea (OSA). However, the mechanism causing hypoxia during sleep in SVCS patients is still uncertain. The aim of this study was to elucidate 1) the changes in central and peripheral respiratory resistance with SVCS, and 2) interpret the mechanism underlying the development of hypoxia during sleep in patients with SVCS related to OSA. Ten SVCS patients related to a neoplasm were recruited for this study. The degree of apnea hypopnea index (AHI) for OSA was evaluated by portable diagnosing device before and after SVCS treatment. We also analyzed the airway resistance and reactance quantitatively in the supine position by Master Screen impulse oscillometry system (MS-IOS?). After SVCS treatment, mean values of AHI were significantly decreased from 30.9 to 16.9 (/hour) (p = 0.001). Central respiratory resistance (R20) also decreased significantly from 0.40 to 0.33 kPa/L/s (p = 0.025) in the supine position. In contrast, peripheral respiratory resistance (R5-R20) and distal capacitive reactance (X5) did not change significantly. It is thought that the exacerbation of OSA due to SVCS is caused by increasing upper airway resistance related to reversible edema of the upper airway mucous or tissue. In contrast, SVCS may not cause peripheral respiratory tract and lung parenchyma edema.
文摘We report here a case of a patient who underwent surgical resection of a giant pericardial cyst that was growing rapidly, causing anterior chest pain. An asymptomatic 56-year-old woman underwent a complete medical checkup in a health-care center. Her chest X-ray showed an unusually large bulge on the left cardiac border, and she was referred to our hospital. The chest X-ray taken 2 years ago in another hospital showed similar bulge on the same left cardiac border, but it was noticeably smaller. Chest CT revealed a 9.5 × 4.5 cm pericardial cyst within the anterolateral aspect of the left cardiac border. The CT number of the mass was approximately 15 - 20 HU. The mass also showed slight hyperintensity on T1-weighted MR images and hyperintensity on T2-weighted MR images. Four weeks later, she experienced anterior chest pain for the first time, and the chest X-ray and CT showed an increase in the size of the pericardial cyst. The CT number of the mass increased to approximately 30 - 40 HU. The cyst was successfully removed by video-assisted thoracic surgery. The pericardial cyst was diagnosed as benign according to the results of histopathology. We conclude that the rapid growth of the pericardial cyst was caused by intracystic hemorrhage that originated from vascularized connective tissue in the cyst wall.
