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Extended therapy duration for therapy-refractory hepatitis C patients with genotype 2
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作者 Ken Sato masatoshi yanagisawa +4 位作者 Hiroaki Hashizume Yuichi Yamazaki Norio Horiguchi Satoru Kakizaki Masatomo Mori 《World Journal of Gastroenterology》 SCIE CAS 2013年第34期5754-5758,共5页
We devised an extended 72-wk peginterferon--2a/ribavirin therapy regimen for the retreatment of highly intractable cases,i.e.,48-wk peginterferon--2b/ribavirin therapy-intractable cases.Although 2 cases achieved a rap... We devised an extended 72-wk peginterferon--2a/ribavirin therapy regimen for the retreatment of highly intractable cases,i.e.,48-wk peginterferon--2b/ribavirin therapy-intractable cases.Although 2 cases achieved a rapid virological response to 72-wk peginterferon--2a/ribavirin therapy,1 case failed to achieve a sustained virological response.Although the reason for this difference in the effectiveness of 72-wk peginterferon--2a/ribavirin therapy between the cases was unclear,the rebound phenomenon of serum transaminase after48-wk peginterferon--2b/ribavirin therapy and the resultant lower viral load compared to that before 48-wk peginterferon--2b/ribavirin therapy might have influenced the treatment outcome.Thus,it may be beneficial to consider the rebound phenomenon of serum transaminase and the changes in viral load resulting from previous interferon-based therapy and then cau-tiously determine the indication and the timing of the administration of 72-wk peginterferon--2a/ribavirin in highly intractable cases.Further studies should be performed to confirm this strategy. 展开更多
关键词 Hepatitis C GENOTYPE 2 and high viral loads Interferon-based THERAPY Highly INTRACTABLE case EXTENDED THERAPY DURATION
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