Purpose To evaluate ocular manifestations associated with dengue fever. Design Retrospective case series and literature review. Methods Clinical records of pa tients with dengue fever who subsequently had ocular sympt...Purpose To evaluate ocular manifestations associated with dengue fever. Design Retrospective case series and literature review. Methods Clinical records of pa tients with dengue fever who subsequently had ocular symptoms and signs develop were reviewed. The clinical presentation and ocular complication s were evaluated. Results Six patients, 5 females and 1 male, were seen with a s udden decrease in vision 6 to 7 days after the initial manifestations of dengue fever were identified. The diagnosis was confirmed by detection of dengue speci fic IgM antibodies (IgM enzyme linked immunoassay). The presenting best correc ted visual acuity ranged from 20/30 to counting fingers, and ocular involvement was bilateral but asymmetric in 5 cases and unilateral in 1 case. Fundus finding s included small, intraretinal, whitish lesions, with localized retinal and reti nal pigment epithelium (RPE) disturbance, small dot hemorrhages, and vascular sh eathing around the macula and the papillomacular bundle. Fluorescein angiography showed arteriolar focal knobby hyperfluorescence at the macula with mild staini ng of the vascular walls and leakage at the level of the RPE.All 5 cases that ha d indocyanine green angiography done showed early diffuse choroidal hyperfluores cence with late silhouetting of the larger choroidal vessels. Five patients rece ived steroid therapy: 1 topical, 2 periocular, and 2 oral. Over 2 to 4 months, R PE discoloration was observed over the affected areas. After the acute episode, 3 patients showed partial recovery of vision, and in the remaining patients, the visual acuity remained stable. Conclusions Ocular complications associated with dengue fever are rare but may result in permanent visual impairment.展开更多
文摘Purpose To evaluate ocular manifestations associated with dengue fever. Design Retrospective case series and literature review. Methods Clinical records of pa tients with dengue fever who subsequently had ocular symptoms and signs develop were reviewed. The clinical presentation and ocular complication s were evaluated. Results Six patients, 5 females and 1 male, were seen with a s udden decrease in vision 6 to 7 days after the initial manifestations of dengue fever were identified. The diagnosis was confirmed by detection of dengue speci fic IgM antibodies (IgM enzyme linked immunoassay). The presenting best correc ted visual acuity ranged from 20/30 to counting fingers, and ocular involvement was bilateral but asymmetric in 5 cases and unilateral in 1 case. Fundus finding s included small, intraretinal, whitish lesions, with localized retinal and reti nal pigment epithelium (RPE) disturbance, small dot hemorrhages, and vascular sh eathing around the macula and the papillomacular bundle. Fluorescein angiography showed arteriolar focal knobby hyperfluorescence at the macula with mild staini ng of the vascular walls and leakage at the level of the RPE.All 5 cases that ha d indocyanine green angiography done showed early diffuse choroidal hyperfluores cence with late silhouetting of the larger choroidal vessels. Five patients rece ived steroid therapy: 1 topical, 2 periocular, and 2 oral. Over 2 to 4 months, R PE discoloration was observed over the affected areas. After the acute episode, 3 patients showed partial recovery of vision, and in the remaining patients, the visual acuity remained stable. Conclusions Ocular complications associated with dengue fever are rare but may result in permanent visual impairment.
