Background Reproducibility is a cornerstone of scientific advancement;however,many published works may lack the core components needed for study reproducibility.Aims In this study,we evaluate the state of transparency...Background Reproducibility is a cornerstone of scientific advancement;however,many published works may lack the core components needed for study reproducibility.Aims In this study,we evaluate the state of transparency and reproducibility in the field of psychiatry using specific indicators as proxies for these practices.Methods An increasing number of publications have investigated indicators of reproducibility,including research by Harwicke etal,from which we based the methodology for our observational,cross-sectional study.From a random 5-year sample of 300 publications in PubMed-indexed psychiatry journals,two researchers extracted data in a duplicate,blinded fashion using a piloted Google form.The publications were examined for indicators of reproducibility and transparency,which included availability of:materials,data,protocol,analysis script,open-access,conflict of interest,funding and online preregistration.Results This study ultimately evaluated 296 randomlyselected publications with a 3.20 median impact factor.Only 107 were available online.Most primary authors originated from USA,UK and the Netherlands.The top three publication types were cohort studies,surveys and clinical trials.Regarding indicators of reproducibility,17 publications gave access to necessary materials,four provided in-depth protocol and one contained raw data required to reproduce the outcomes.One publication offered its analysis script on request;four provided a protocol availability statement.Only 107 publications were publicly available:13 were registered in online repositories and four,ten and eight publications included their hypothesis,methods and analysis,respectively.Conflict of interest was addressed by 177 and reported by 31 publications.Of 185 publications with a funding statement,153 publications were funded and 32 were unfunded.Conclusions Currently,Psychiatry research has significant potential to improve adherence to reproducibility and transparency practices.Thus,this study presents a reference point for the state of reproducibility and transparency in Psychiatry literature.Future assessments are recommended to evaluate and encourage progress.展开更多
《循证医学宣言》(The Evidence-Based Medicine Manifesto)概述了收集更可信证据的步骤。这些步骤包括减少利益冲突,制订更加完善、适用的临床实践指南。本文作者认为,指南制定小组成员自行公开的企业资助情况是不充分的,也常常是不准...《循证医学宣言》(The Evidence-Based Medicine Manifesto)概述了收集更可信证据的步骤。这些步骤包括减少利益冲突,制订更加完善、适用的临床实践指南。本文作者认为,指南制定小组成员自行公开的企业资助情况是不充分的,也常常是不准确的。国际社会应该团结起来,共同要求将药品和医疗器械公司支付给医生的行业资助公开透明地发布出来。这样的倡议可以实现诸多目标,如制订更好的政策、审核指南制定专家成员涉及的利益冲突。展开更多
基金This study was funded through the 2019 Presidential Research Fellowship Mentor-Mentee Program at Oklahoma State University Center for Health Sciences.
文摘Background Reproducibility is a cornerstone of scientific advancement;however,many published works may lack the core components needed for study reproducibility.Aims In this study,we evaluate the state of transparency and reproducibility in the field of psychiatry using specific indicators as proxies for these practices.Methods An increasing number of publications have investigated indicators of reproducibility,including research by Harwicke etal,from which we based the methodology for our observational,cross-sectional study.From a random 5-year sample of 300 publications in PubMed-indexed psychiatry journals,two researchers extracted data in a duplicate,blinded fashion using a piloted Google form.The publications were examined for indicators of reproducibility and transparency,which included availability of:materials,data,protocol,analysis script,open-access,conflict of interest,funding and online preregistration.Results This study ultimately evaluated 296 randomlyselected publications with a 3.20 median impact factor.Only 107 were available online.Most primary authors originated from USA,UK and the Netherlands.The top three publication types were cohort studies,surveys and clinical trials.Regarding indicators of reproducibility,17 publications gave access to necessary materials,four provided in-depth protocol and one contained raw data required to reproduce the outcomes.One publication offered its analysis script on request;four provided a protocol availability statement.Only 107 publications were publicly available:13 were registered in online repositories and four,ten and eight publications included their hypothesis,methods and analysis,respectively.Conflict of interest was addressed by 177 and reported by 31 publications.Of 185 publications with a funding statement,153 publications were funded and 32 were unfunded.Conclusions Currently,Psychiatry research has significant potential to improve adherence to reproducibility and transparency practices.Thus,this study presents a reference point for the state of reproducibility and transparency in Psychiatry literature.Future assessments are recommended to evaluate and encourage progress.
文摘《循证医学宣言》(The Evidence-Based Medicine Manifesto)概述了收集更可信证据的步骤。这些步骤包括减少利益冲突,制订更加完善、适用的临床实践指南。本文作者认为,指南制定小组成员自行公开的企业资助情况是不充分的,也常常是不准确的。国际社会应该团结起来,共同要求将药品和医疗器械公司支付给医生的行业资助公开透明地发布出来。这样的倡议可以实现诸多目标,如制订更好的政策、审核指南制定专家成员涉及的利益冲突。
