Membrane contact sites (MCS) occur between closely apposed organelles and are a means to transport ions and macromolecules between themselves,co-ordinate cellular metabolism,and direct organelle fission and transport....Membrane contact sites (MCS) occur between closely apposed organelles and are a means to transport ions and macromolecules between themselves,co-ordinate cellular metabolism,and direct organelle fission and transport.While MCS between the endoplasmic reticulum (ER)and mitochondria has long been investigated。展开更多
Autosomal recessive mutations in the PARK7 gene,which encodes for the protein DJ-1,result in a loss of function and are a cause of familial Parkinson’s disease（PD）,while increased wild-type DJ-1protein levels are a...Autosomal recessive mutations in the PARK7 gene,which encodes for the protein DJ-1,result in a loss of function and are a cause of familial Parkinson’s disease（PD）,while increased wild-type DJ-1protein levels are associated with some forms of cancer.Several functions of DJ-1 have been described,with the greatest evidence indicating that DJ-1 is a redox-sensitive protein involved in the regulation of oxidative stress and cell survival.展开更多
文摘Membrane contact sites (MCS) occur between closely apposed organelles and are a means to transport ions and macromolecules between themselves,co-ordinate cellular metabolism,and direct organelle fission and transport.While MCS between the endoplasmic reticulum (ER)and mitochondria has long been investigated。
基金funded by a Medical Research Council(UK)Experimental Medicine grant[MR/M006646/1]
文摘Autosomal recessive mutations in the PARK7 gene,which encodes for the protein DJ-1,result in a loss of function and are a cause of familial Parkinson’s disease（PD）,while increased wild-type DJ-1protein levels are associated with some forms of cancer.Several functions of DJ-1 have been described,with the greatest evidence indicating that DJ-1 is a redox-sensitive protein involved in the regulation of oxidative stress and cell survival.
