Autosomal recessive mutations in the PARK7 gene,which encodes for the protein DJ-1,result in a loss of function and are a cause of familial Parkinson’s disease（PD）,while increased wild-type DJ-1protein levels are a...Autosomal recessive mutations in the PARK7 gene,which encodes for the protein DJ-1,result in a loss of function and are a cause of familial Parkinson’s disease（PD）,while increased wild-type DJ-1protein levels are associated with some forms of cancer.Several functions of DJ-1 have been described,with the greatest evidence indicating that DJ-1 is a redox-sensitive protein involved in the regulation of oxidative stress and cell survival.展开更多
Membrane contact sites (MCS) occur between closely apposed organelles and are a means to transport ions and macromolecules between themselves,co-ordinate cellular metabolism,and direct organelle fission and transport....Membrane contact sites (MCS) occur between closely apposed organelles and are a means to transport ions and macromolecules between themselves,co-ordinate cellular metabolism,and direct organelle fission and transport.While MCS between the endoplasmic reticulum (ER)and mitochondria has long been investigated。展开更多
基金funded by a Medical Research Council(UK)Experimental Medicine grant[MR/M006646/1]
文摘Autosomal recessive mutations in the PARK7 gene,which encodes for the protein DJ-1,result in a loss of function and are a cause of familial Parkinson’s disease（PD）,while increased wild-type DJ-1protein levels are associated with some forms of cancer.Several functions of DJ-1 have been described,with the greatest evidence indicating that DJ-1 is a redox-sensitive protein involved in the regulation of oxidative stress and cell survival.
文摘Membrane contact sites (MCS) occur between closely apposed organelles and are a means to transport ions and macromolecules between themselves,co-ordinate cellular metabolism,and direct organelle fission and transport.While MCS between the endoplasmic reticulum (ER)and mitochondria has long been investigated。
