A Review of Clinical Applications for Super-resolution Ultrasound Localization Microscopy

Microvascular structure and hemodynamics are important indicators for the diagnosis and assessment of many diseases and pathologies.The structural and functional imaging of tissue microvasculature in vivo is a clinically significant objective for the development of many imaging modalities.Contrast-enhanced ultrasound(CEUS)is a popular clinical tool for characterizing tissue microvasculature,due to the moderate cost,wide accessibility,and absence of ionizing radiation of ultrasound.

Three-Dimensional Shear Wave Elastography Using a 2D Row Column Addressing(RCA)Array

Objective.To develop a 3D shear wave elastography(SWE)technique using a 2D row column addressing(RCA)array,with either external vibration or acoustic radiation force(ARF)as the shear wave source.Impact Statement.The proposed method paves the way for clinical translation of 3D SWE based on the 2D RCA,providing a low-cost and high volume rate solution that is compatible with existing clinical systems.Introduction.SWE is an established ultrasound imaging modality that provides a direct and quantitative assessment of tissue stiffness,which is significant for a wide range of clinical applications including cancer and liver fibrosis.SWE requires high frame rate imaging for robust shear wave tracking.Due to the technical challenges associated with high volume rate imaging in 3D,current SWE techniques are typically confined to 2D.Advancing SWE from 2D to 3D is significant because of the heterogeneous nature of tissue,which demands 3D imaging for accurate and comprehensive evaluation.Methods.A 3D SWE method using a RCA array was developed with a volume rate up to 2000 Hz.The performance of the proposed method was systematically evaluated on tissue-mimicking elasticity phantoms and in an in vivo case study.Results.3D shear wave motion induced by either external vibration or ARF was successfully detected with the proposed method.Robust 3D shear wave speed maps were reconstructed for phantoms and in vivo.Conclusion.The high volume rate 3D imaging provided by the 2D RCA array provides a robust and practical solution for 3D SWE with a clear pathway for future clinical translation.