BACKGROUND Black women are known to have a higher risk of aggressive endometrial cancers.Little data exist about the role of nativity as a determinant of survival outcomes in women with this disease.AIM Our objective ...BACKGROUND Black women are known to have a higher risk of aggressive endometrial cancers.Little data exist about the role of nativity as a determinant of survival outcomes in women with this disease.AIM Our objective was to evaluate a population of Haitian immigrants with endometrial cancer in an urban setting using the Florida Cancer Data System(FCDS).METHODS A search of FCDS identified 107 women born in Haiti and who received treatment for invasive endometrial cancer in Miami-Dade County between 1989 and 2013.Clinicopathologic data were extracted to describe the cohort and assess associations with overall survival.Statistical analyses were performed using Cox proportional hazards models,the log-rank test,and the Kaplan-Meier method,with significance set at P≤0.05.RESULTS Median age at diagnosis was 65 years.63.9%of the patients had a typeⅡ,highgrade,histology,and 52.6%presented with extrauterine metastatic disease.Nearly three quarters had health insurance.Within the entire cohort,only presence of extrauterine disease was associated with worse overall survival[Hazard ratio(HR)=2.70,95%confidence interval(CI):1.31-5.57,P=0.007].However,after stratification by histologic grade,both age(HR=0.88,95%CI:0.81-0.96,P=0.002)and extrauterine disease(HR=2.49,95%CI:1.01-6.21,P=0.049)were independently associated with worse survival,but only in women with typeⅡmalignancies.CONCLUSION Urban Haitian women with endometrial cancer have a high burden of aggressive histologies.Additional investigation to explain the etiology of these findings is needed.展开更多
文摘BACKGROUND Black women are known to have a higher risk of aggressive endometrial cancers.Little data exist about the role of nativity as a determinant of survival outcomes in women with this disease.AIM Our objective was to evaluate a population of Haitian immigrants with endometrial cancer in an urban setting using the Florida Cancer Data System(FCDS).METHODS A search of FCDS identified 107 women born in Haiti and who received treatment for invasive endometrial cancer in Miami-Dade County between 1989 and 2013.Clinicopathologic data were extracted to describe the cohort and assess associations with overall survival.Statistical analyses were performed using Cox proportional hazards models,the log-rank test,and the Kaplan-Meier method,with significance set at P≤0.05.RESULTS Median age at diagnosis was 65 years.63.9%of the patients had a typeⅡ,highgrade,histology,and 52.6%presented with extrauterine metastatic disease.Nearly three quarters had health insurance.Within the entire cohort,only presence of extrauterine disease was associated with worse overall survival[Hazard ratio(HR)=2.70,95%confidence interval(CI):1.31-5.57,P=0.007].However,after stratification by histologic grade,both age(HR=0.88,95%CI:0.81-0.96,P=0.002)and extrauterine disease(HR=2.49,95%CI:1.01-6.21,P=0.049)were independently associated with worse survival,but only in women with typeⅡmalignancies.CONCLUSION Urban Haitian women with endometrial cancer have a high burden of aggressive histologies.Additional investigation to explain the etiology of these findings is needed.
