Background and Aims:Metabolic-associated fatty liver disease(MAFLD)is driven by high caloric intake and sedentary lifestyle.Migration towards high income countries may induce these driving factors;yet,the influence of...Background and Aims:Metabolic-associated fatty liver disease(MAFLD)is driven by high caloric intake and sedentary lifestyle.Migration towards high income countries may induce these driving factors;yet,the influence of such on the prevalence of MAFLD is clearly understudied.Here,we investigated the Fatty Liver Index(FLI),a proxy of steatosis in MAFLD,after migration of Ghanaian subjects.Methods:Cross-sectional data of 5282 rural,urban and migrant participants from the Research on Obesity and Diabetes among African Migrants(also known as RODAM)study were analyzed with logistic regression for geographical differences in FLI and associations with type 2 diabetes mellitus(T2DM),waist-to-hip ratio,and 10-year predicted risk of atherosclerotic cardiovascular disease(ASCVD).Results:Both FLI and the proportion with an FLI indicative of MAFLD steatosis(FLI≥60)were higher in migrants compared with non-migrants.Prevalence of elevated FLI(FLI≥60)in non-migrant males was 4.2%compared to 28.9%in migrants.For females,a similar gradient was observed,from 13.6%to 36.6%respectively.Compared to rural residents,the odds for a FLI≥60 were higher in migrants living in urban Europe(odds ratio[OR]9.02,95%confidence interval[CI]:5.02–16.20 for men,and 4.00,95%CI:3.00–5.34 for women).Compared to controls,the ORs for FLI≥60 were 2.43(95%CI:1.73–3.41)for male T2DM cases and 2.02(95%CI:1.52–2.69)for female T2DM cases.One-unit higher FLI was associated with an elevated(≥7.5%)10-year ASCVD risk(OR:1.051,95%CI:1.041–1.062 for men,and 1.020,95%CI:1.015–1.026 for women).Conclusions:FLI as a proxy for MAFLD increased stepwise in Ghanaians from rural areas,through urban areas,to Europe.Our results clearly warrant awareness for MAFLD in migrant population as well as confirmation with imaging modalities.展开更多
Dear Editor,In the European region,which shares 22.8%of the global cancer burden for 10%of the global population,there were around 4.4 million new cancer cases and 1.9 million deaths from cancer in 2020[1].The reasons...Dear Editor,In the European region,which shares 22.8%of the global cancer burden for 10%of the global population,there were around 4.4 million new cancer cases and 1.9 million deaths from cancer in 2020[1].The reasons for the high cancer incidence rates are complex;however,diet and dietary components are among the main contributors to cancer risk[2].In modern-day living,a growing proportion of people include in their diets ultra-processed foods.Byproducts of food processing and home-prepared foods are so-called dietary advanced glycation endproducts(AGEs),which are reactive metabolites emerging during the breakdown of reducing sugar.AGEs production is preponderant in dry high-heat processes(e.g.,baking,roasting);hence foods such as cakes,crisps,crackers,cereal products,meat and meat-derived products represent a major source of dietary AGEs[3].展开更多
基金This work was supported by the European Commission under the Framework Programme(Grant No.278901)The study sponsor was not involved in the design of the study+3 种基金the collection,analysis and interpretation of datawriting the reportnor the decision to submit the report for publication.AGH was supported by the Amsterdam UMC Fellowship grant,a Holland Health TKI-PPP grant and by research grants from Gilead and Novo Nordisk.KACM was supported by the Intramural Research Program of the National Institutes of Health in the Center for Research on Genomics and Global Health(CRGGH)The CRGGH was supported by the National Human Genome Research Institute,the National Institute of Diabetes and Digestive and Kidney Diseases,the Center for Information Technology,and the Office of the Director at the National Institutes of Health(No.1ZIAHG200362).
文摘Background and Aims:Metabolic-associated fatty liver disease(MAFLD)is driven by high caloric intake and sedentary lifestyle.Migration towards high income countries may induce these driving factors;yet,the influence of such on the prevalence of MAFLD is clearly understudied.Here,we investigated the Fatty Liver Index(FLI),a proxy of steatosis in MAFLD,after migration of Ghanaian subjects.Methods:Cross-sectional data of 5282 rural,urban and migrant participants from the Research on Obesity and Diabetes among African Migrants(also known as RODAM)study were analyzed with logistic regression for geographical differences in FLI and associations with type 2 diabetes mellitus(T2DM),waist-to-hip ratio,and 10-year predicted risk of atherosclerotic cardiovascular disease(ASCVD).Results:Both FLI and the proportion with an FLI indicative of MAFLD steatosis(FLI≥60)were higher in migrants compared with non-migrants.Prevalence of elevated FLI(FLI≥60)in non-migrant males was 4.2%compared to 28.9%in migrants.For females,a similar gradient was observed,from 13.6%to 36.6%respectively.Compared to rural residents,the odds for a FLI≥60 were higher in migrants living in urban Europe(odds ratio[OR]9.02,95%confidence interval[CI]:5.02–16.20 for men,and 4.00,95%CI:3.00–5.34 for women).Compared to controls,the ORs for FLI≥60 were 2.43(95%CI:1.73–3.41)for male T2DM cases and 2.02(95%CI:1.52–2.69)for female T2DM cases.One-unit higher FLI was associated with an elevated(≥7.5%)10-year ASCVD risk(OR:1.051,95%CI:1.041–1.062 for men,and 1.020,95%CI:1.015–1.026 for women).Conclusions:FLI as a proxy for MAFLD increased stepwise in Ghanaians from rural areas,through urban areas,to Europe.Our results clearly warrant awareness for MAFLD in migrant population as well as confirmation with imaging modalities.
基金the Fondation de France(FDF,grant no.00081166,HF and RC,and FDF grant no.00089811,ALM)the Wereld Kanker Onderzoek Fonds(WKOF),as part of the World Cancer Research Fund(WCRF)International grant programme(WCRF 2015-1391,PI Dr.Mazda Jenab,International Agency for Research on Cancer)。
文摘Dear Editor,In the European region,which shares 22.8%of the global cancer burden for 10%of the global population,there were around 4.4 million new cancer cases and 1.9 million deaths from cancer in 2020[1].The reasons for the high cancer incidence rates are complex;however,diet and dietary components are among the main contributors to cancer risk[2].In modern-day living,a growing proportion of people include in their diets ultra-processed foods.Byproducts of food processing and home-prepared foods are so-called dietary advanced glycation endproducts(AGEs),which are reactive metabolites emerging during the breakdown of reducing sugar.AGEs production is preponderant in dry high-heat processes(e.g.,baking,roasting);hence foods such as cakes,crisps,crackers,cereal products,meat and meat-derived products represent a major source of dietary AGEs[3].
