In a recent article in Nature,Muthusami et al.1 highlight the promiscuity of serine palmitoyltransferase(SPT)for non-essential amino acids under low serine conditions,illustrating a previously unappreciated mechanism ...In a recent article in Nature,Muthusami et al.1 highlight the promiscuity of serine palmitoyltransferase(SPT)for non-essential amino acids under low serine conditions,illustrating a previously unappreciated mechanism for inhibition of tumour growth—increased levels of deoxysphingolipids.展开更多
基金O.D.K.M and M.F.are funded by a Cancer Research UK Career Development Fellowship(C53309/A19702).
文摘In a recent article in Nature,Muthusami et al.1 highlight the promiscuity of serine palmitoyltransferase(SPT)for non-essential amino acids under low serine conditions,illustrating a previously unappreciated mechanism for inhibition of tumour growth—increased levels of deoxysphingolipids.
