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Factors that influence adult neurogenesis as potential therapy 被引量:8
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作者 Belal Shohayeb Mohamed Diab +1 位作者 mazen ahmed Dominic Chi Hiung Ng 《Translational Neurodegeneration》 SCIE CAS 2018年第1期24-42,共19页
Adult neurogenesis involves persistent proliferative neuroprogenitor populations that reside within distinct regions of the brain.This phenomenon was first described over 50 years ago and it is now firmly established ... Adult neurogenesis involves persistent proliferative neuroprogenitor populations that reside within distinct regions of the brain.This phenomenon was first described over 50 years ago and it is now firmly established that new neurons are continually generated in distinct regions of the adult brain.The potential of enhancing the neurogenic process lies in improved brain cognition and neuronal plasticity particularly in the context of neuronal injury and neurodegenerative disorders.In addition,adult neurogenesis might also play a role in mood and affective disorders.The factors that regulate adult neurogenesis have been broadly studied.However,the underlying molecular mechanisms of regulating neurogenesis are still not fully defined.In this review,we will provide critical analysis of our current understanding of the factors and molecular mechanisms that determine neurogenesis.We will further discuss pre-clinical and clinical studies that have investigated the potential of modulating neurogenesis as therapeutic intervention in neurodegeneration. 展开更多
关键词 NICHE NEUROTROPHINS CYTOKINES Transcription factors Stem cells Extrinsic factors THERAPY
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