Despite its high prevalence, nonulcer dyspepsia is still difficult to study, d ue to the lack of adequate tools to measure significant outcomes. The objective of this study was to develop and validate a symptom-focuse...Despite its high prevalence, nonulcer dyspepsia is still difficult to study, d ue to the lack of adequate tools to measure significant outcomes. The objective of this study was to develop and validate a symptom-focused, disease- -specific questionnaire to evaluate patients with nonulcer dyspepsia. For tha t, the questionnaire was carefully written following widely accepted terminology , so as to facilitate translation and validation in other languages and cultures . The questionnaire was developed using Rome I terminology for symptoms, which w ere evaluated according to their intensity, duration, and frequency when applica ble.Thirty-one patients with nonulcer dyspepsia, as well as 31 sex and age-mat ched volunteers without digestive problems were used to assess the internal cons istency, reproducibility,responsiveness, content validity, and discriminant vali dity of the questionnaire. Another 31 functional dyspeptic patients were enrolle d for assessment of criterion validity. Cronbach’s αcoefficient was 0.82. The intraclass correlation coefficient for the scores obtained 7 days apart was 0.86 . The mean score obtained after 3 months of treatment was 16.4, vs. 23.03 at bas eline (P = 0.001). Two blinded gastroenterologists agreed that the questionnaire adequately evaluated nonulcer dyspepsia.The median symptoms score for controls was 0, vs. 22.5 for dyspeptic patients (P = 0.001). An inverse correlation was o bserved between quality of life and dyspeptic symptoms (R=-0.28, P = 0.026). Th e proposed questionnaire has high degrees of both reproducibility and responsive ness. As this questionnaire was based on Rome I International Consensus terminol ogy, it is expected that it will be easy to translate and validate.展开更多
文摘Despite its high prevalence, nonulcer dyspepsia is still difficult to study, d ue to the lack of adequate tools to measure significant outcomes. The objective of this study was to develop and validate a symptom-focused, disease- -specific questionnaire to evaluate patients with nonulcer dyspepsia. For tha t, the questionnaire was carefully written following widely accepted terminology , so as to facilitate translation and validation in other languages and cultures . The questionnaire was developed using Rome I terminology for symptoms, which w ere evaluated according to their intensity, duration, and frequency when applica ble.Thirty-one patients with nonulcer dyspepsia, as well as 31 sex and age-mat ched volunteers without digestive problems were used to assess the internal cons istency, reproducibility,responsiveness, content validity, and discriminant vali dity of the questionnaire. Another 31 functional dyspeptic patients were enrolle d for assessment of criterion validity. Cronbach’s αcoefficient was 0.82. The intraclass correlation coefficient for the scores obtained 7 days apart was 0.86 . The mean score obtained after 3 months of treatment was 16.4, vs. 23.03 at bas eline (P = 0.001). Two blinded gastroenterologists agreed that the questionnaire adequately evaluated nonulcer dyspepsia.The median symptoms score for controls was 0, vs. 22.5 for dyspeptic patients (P = 0.001). An inverse correlation was o bserved between quality of life and dyspeptic symptoms (R=-0.28, P = 0.026). Th e proposed questionnaire has high degrees of both reproducibility and responsive ness. As this questionnaire was based on Rome I International Consensus terminol ogy, it is expected that it will be easy to translate and validate.
