Quality Control of Gamma Camera with SPECT Systems

Quality control of Gamma Camera with SPECT System is highly valuable for assurance performance characteristic. We report the performance characteristic of gamma camera by intrinsic calibration and verification measurement. The study has been done using the data from Siemens Symbia S Series gamma camera by using a point source 99mTc at the Institute of Nuclear Medicine & Allied Sciences (INMAS), Khulna, Bangladesh. From intrinsic calibration and verification flood series, the integral uniformity for the central field of view (CFOV) has been found in between 4.01% and 2.88% and for the useful field of view (UFOV) has been in between 4.77% and 4.30%. The differential uniformity for the CFOV has been in between 1.53% and 2.04% and for the UFOV has been in between 2.32% and 2.77%. According to Operating Instruction Symbia System S Series manual, uniformity can compensate for values exceeding 10%, however while integral uniformity exceed 7%, have to contract Siemens customer service representative. In conclusion, these results show that the intrinsic uniformity of the gamma camera under this condition is within an acceptable range;thus the gamma camera working in INMAS is performed well.

CAR T Cell Immunotherapy That Revolutionary Breakthrough in Human Oncology Treatment: A Review

The discovery of CAR T cell immunotherapy, also known as chimeric antigen receptor (CAR) T cell immunotherapy, has added a new dimension to the world of cancer treatment. This is a gene-based treatment in which T cells from the patient’s body are taken and genetically engineered in the lab to grow receptors. T cells containing this receptor are then injected into the patient’s body to bind to the antigen on the surface area of the cancer cell and kill the cancer cell. Structurally, the co-stimulatory domain added to CAR T cells has now reached the 5th GEN of chimeric antigen receptor T cells. Chimeric antigen T cell immunotherapy is the first FDA-approved treatment for hematological malignancies that is both safe and effective. However, due to some challenges such as a lack of safety control, an immunosuppressive tumor microenvironment, ineffective T cell trafficking, and so on, CAR-T immunotherapy treatment for solid malignancy is still in the clinical phase. In the result and discussion, we have presented a survey of CAR T cell therapy with a combination of pharmacological drugs. The things we mentioned are that CAR T cell immunotherapy is innovative, suitable, elegant, and also controls synergistic anti-cancer effects. A better understanding of combinatory CAR T cell therapies provides fundamental information for improvement of those therapies, in addition to the article highlighting future opportunities, commercial advancements, and various applications of CAR T cell therapy in different cancer cells. In the entire review article, we have highlighted the neck and crop of CAR T cell therapy, from which it is easy to understand the therapy and the need for this therapy in cancer prevention and its progress.

Competitiveness of Winter Rice Varieties against Weed under Dry Direct Seeded Conditions

Aerobic rice or dry direct seeded rice is highly vulnerable to weeds because of lack of “head start” over weeds and standing water layer to suppress weeds. The risks of chemical control and the huge cost involvement in mechanical control demand an eco-friendly and cost-effective integrated weed management. Weed competitive rice cultivar may be considered as a viable tool for integrated weed management. In these circumstances, an experiment was designed to evaluate weed competitiveness of some selected winter rice varieties under aerobic soil conditions. The study was conducted during dry season (February to June) 2016 at the Agronomy Field Laboratory and Weed Management Laboratory, Bangladesh Agricultural University, Mymensingh. Fourteen rice varieties namely, BRRI dhan28, BRRI dhan29, BRRI dhan47, BRRI dhan50, BRRI dhan55, BRRI dhan58, BRRI dhan59, BRRI dhan67, Binadhan-5, Binadhan-6, Binadhan-8, Binadhan-10, BRRI hybrid dhan3 and Agrodhan-14 were grown under weedy and weed-free conditions. Plots with no rice were also maintained to observe the natural growth of weed in absence of rice. The experiment was conducted with split-plot design with three replications. Weeding regime was allocated in main plot and rice variety was allocated in sub-plot. Results showed that rice varieties varied widely in their yield performances and weed competitiveness. Among rice varieties, BRRI dhan59 allowed the minimum weed growth (19.2 g m-2) while Binadhan-5 allowed the maximum weed growth (62.8 g m-2). Grain yield ranged from 1.85 t ha-1 (BRRI dhan55) to 3.92 t ha-1 (Binadhan-5) under weed-free condition and between 0.41 t ha-1 (BRRI dhan55) and 2.06 t ha-1 (BRRI dhan59) under weedy condition. Weed inflicted relative yield loss ranged from 43.4% to 82.1% among the varieties. BRRI dhan59 allowed the least yield penalty (43.4%) while Binadhan-5 had the maximum yield penalty (82.1%) due to weed competition. Although Binadhan-5 is the most productive variety (3.92 t ha-1) for aerobic culture but its weed inflicted relative yield loss is higher (82.1%) than many other varieties with low yield potential. On the other hand, BRRI dhan59 appeared as the most weed competitive variety (only 43.4% relative yield loss) with productivity of 3.84 t ha-1. Therefore, weed competitive variety should be considered as a vital tool while designing integrated weed management system for aerobic rice.