Although oxidation is the most common biological and energy producing reaction, oxidative stress is harmful to cell, because the products of oxidation such as free radicals and peroxides damage the cellular components...Although oxidation is the most common biological and energy producing reaction, oxidative stress is harmful to cell, because the products of oxidation such as free radicals and peroxides damage the cellular components, causing several diseases. Damage in DNA is responsible for cancer formation and progression. However, several enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase etc. act as antioxidants to influence oxidative stress. Polymorphisms in these enzymes are supposed to be associated with DNA damage and subsequently the individual＇s risk of cancer susceptibility. This review article aims to further elucidate the relationship between antioxidant enzymes and cancers by summarizing the findings of some of the important study concerning expression levels and genetic polymorphisms of antioxidant enzymes in cancer patients.展开更多
Phyto-chemicals are increasingly being used in the treatment of cancer because of their availability,potential anti-cancer activity with less adverse effects when compared with chemotherapy.The variation of climate an...Phyto-chemicals are increasingly being used in the treatment of cancer because of their availability,potential anti-cancer activity with less adverse effects when compared with chemotherapy.The variation of climate and geography in South Asian countries provides a nursing environment for the growth of versatile plant species,that are repeatedly drawing attention of the scientific community.In this review,we have focused on the anti-cancer potential of thirty plants,which are commonly found in Bangladesh,India,Nepal,Pakistan and Sri Lanka,with their mechanisms of action.In particular,we have discussed the bio-active components that display anti-cancer activity,which have been identified in these plants.This review may help researchers to profile plants with known anti-cancer effect of this region and further investigations of anti-cancer agents in medicinal plants from South Asia.展开更多
基金supported by the National Natural Science Foundation of China(No.30371660)the grant from the Chinese Medical Board(CMB) of New York(No.99-698).
文摘Although oxidation is the most common biological and energy producing reaction, oxidative stress is harmful to cell, because the products of oxidation such as free radicals and peroxides damage the cellular components, causing several diseases. Damage in DNA is responsible for cancer formation and progression. However, several enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase etc. act as antioxidants to influence oxidative stress. Polymorphisms in these enzymes are supposed to be associated with DNA damage and subsequently the individual＇s risk of cancer susceptibility. This review article aims to further elucidate the relationship between antioxidant enzymes and cancers by summarizing the findings of some of the important study concerning expression levels and genetic polymorphisms of antioxidant enzymes in cancer patients.
文摘Phyto-chemicals are increasingly being used in the treatment of cancer because of their availability,potential anti-cancer activity with less adverse effects when compared with chemotherapy.The variation of climate and geography in South Asian countries provides a nursing environment for the growth of versatile plant species,that are repeatedly drawing attention of the scientific community.In this review,we have focused on the anti-cancer potential of thirty plants,which are commonly found in Bangladesh,India,Nepal,Pakistan and Sri Lanka,with their mechanisms of action.In particular,we have discussed the bio-active components that display anti-cancer activity,which have been identified in these plants.This review may help researchers to profile plants with known anti-cancer effect of this region and further investigations of anti-cancer agents in medicinal plants from South Asia.
