PURPOSE: To investigate the association between patterns of visual field (VF) loss and retinal nerve fiber layer (RNFL) thickness measurements. DESIGN: Observational cross-sectional study. METHODS: One hundred twenty-...PURPOSE: To investigate the association between patterns of visual field (VF) loss and retinal nerve fiber layer (RNFL) thickness measurements. DESIGN: Observational cross-sectional study. METHODS: One hundred twenty-one glaucoma patients and 65 healthy subjects from the Diagnostic Innovations in Glaucoma Study (DIGS) were included. All glaucoma patients had repeatable abnormal VFs and scanning laser polarimetry (SLP) RNFL thickness measurements. RNFL measurements were obtained from 16 equal parapapillary sectors. Patterns of VF loss were classified as arcuate,partial arcuate,nasal step,or paracentral in each VF hemifield. Logistic regression analysis was performed to determine which RNFL sectors were associated with each VF pattern. The ability of SLP to discriminate between eyes with different VF patterns and healthy eyes using receiver operating characteristic (ROC) curve analyses also was investigated. RESULTS: VF patterns in the superior hemifield were significantly associated with RNFL sectors in the temporal inferior hemiretina (P < .05). ROC curve areas for discrimination between eyes with differentVF patterns and healthy eyes ranged from 0.85 to 0.95. VF patterns in the inferior hemifield were most strongly associated with temporal superior RNFL sectors (P < .05). ROC curve areas for discrimination between different VF patterns and healthy eyes ranged from 0.73 to 0.98. SLP could discriminate between apparently unaffected VF hemifields in glaucoma eyes and VF hemifields in healthy eyes. CONCLUSIONS: Parapapillary RNFL thickness was topographically related to patterns of VF loss. SLP can differentiate between apparently unaffected VF hemifields in glaucoma eyes and normal VF hemifields in healthy eyes.展开更多
Purpose: To examine the relationship between retinal nerve fiber layer (RNFL) measurements obtained using scanning laser polarimetry with variable corneal compensation and corneal thickness measurements in ocular hype...Purpose: To examine the relationship between retinal nerve fiber layer (RNFL) measurements obtained using scanning laser polarimetry with variable corneal compensation and corneal thickness measurements in ocular hypertension (OHT) patients. Design: Observational cross- sectional study. Subjects: The study included 1 eye each from44 OHT patients and48 healthy subjects, all of similar age. All subjects had normal optic discs and normal standard automated perimetry (SAP) visual fields. Ocular hypertension patients had intraocular pressure (IOP) measurements higher than 22 mmHg. Methods: All patients underwent imagingwith the GDx VCC (Laser Diagnostic Technologies, Inc., San Diego, CA) scanning laser polarimeter. We examined the relationship between GDx VCC RNFL measurements and central corneal thickness, a risk factor for development of visual field loss among OHT patients. We also examined the relationship of GDx VCC measurements and age, IOP, SAP pattern standard deviation, and vertical cup- todisc ratio. Main Outcome Measures: Central corneal thickness (CCT) and GDx VCC RNFL thickness parameters. Results: Central corneal thickness measurements in OHT patients were significantly higher than those in healthy subjects (575± 30 μ m vs.555± 32 μ m; P=0.002). Higher GDx VCC parameter nerve fiber indicator (NFI) scores, indicating thinner RNFL, were correlated significantly with thinner CCT measurements in OHT patients (r=- 0.502; P=0.001). Ocular hypertension patients with thinner corneas (n=22; mean CCT,553± 21 μ m)- had significantly higher NFI scores than OHT patients with thicker corneas (n=22; mean CCT,598± 18 μ m) and healthy control subjects (NFI mean± standard deviation, 26.9± 9.5, 20.7± 9.8, and 19.7± 7.0, respectively; P=0.004, analysis of variance). The NFI values were not significantly different between OHT patients with thicker corneas and healthy subjects. In multivariate analysis, only age and CCT measurement were associated significantly with GDx VCC RNFL measurements in OHT eyes. Conclusions: Ocular hypertension patients with thinner corneas had significantly thinner RNFL than OHT patients with thicker corneas and healthy control subjects. These findings support the notion thatRNFL defects as assessed by the GDx VCC may represent early glaucomatous damage in OHT eyes.展开更多
Purpose: To report the use of argon laser peripheral iridoplasty in the treatment of plateau- like iris configuration as a result of iris and ciliary body cysts. Design: Case report. Methods: A43- year- old male with ...Purpose: To report the use of argon laser peripheral iridoplasty in the treatment of plateau- like iris configuration as a result of iris and ciliary body cysts. Design: Case report. Methods: A43- year- old male with plateau iris syndrome was demonstrated by high frequency ultrasound biomicroscopy (UBM), to have numerous iris and ciliary body cysts. Bilateral argon laser peripheral iridoplasty was performed. Results: Argon laser iridoplasty opened the drainage angle in both eyes. Conclusion: Argon laser iridoplasty is an effective and safe treatment for plateau iris syndrome and may also prove valuable in the treatment of plateau- like iris configuration resulting from iridociliary cysts.展开更多
文摘PURPOSE: To investigate the association between patterns of visual field (VF) loss and retinal nerve fiber layer (RNFL) thickness measurements. DESIGN: Observational cross-sectional study. METHODS: One hundred twenty-one glaucoma patients and 65 healthy subjects from the Diagnostic Innovations in Glaucoma Study (DIGS) were included. All glaucoma patients had repeatable abnormal VFs and scanning laser polarimetry (SLP) RNFL thickness measurements. RNFL measurements were obtained from 16 equal parapapillary sectors. Patterns of VF loss were classified as arcuate,partial arcuate,nasal step,or paracentral in each VF hemifield. Logistic regression analysis was performed to determine which RNFL sectors were associated with each VF pattern. The ability of SLP to discriminate between eyes with different VF patterns and healthy eyes using receiver operating characteristic (ROC) curve analyses also was investigated. RESULTS: VF patterns in the superior hemifield were significantly associated with RNFL sectors in the temporal inferior hemiretina (P < .05). ROC curve areas for discrimination between eyes with differentVF patterns and healthy eyes ranged from 0.85 to 0.95. VF patterns in the inferior hemifield were most strongly associated with temporal superior RNFL sectors (P < .05). ROC curve areas for discrimination between different VF patterns and healthy eyes ranged from 0.73 to 0.98. SLP could discriminate between apparently unaffected VF hemifields in glaucoma eyes and VF hemifields in healthy eyes. CONCLUSIONS: Parapapillary RNFL thickness was topographically related to patterns of VF loss. SLP can differentiate between apparently unaffected VF hemifields in glaucoma eyes and normal VF hemifields in healthy eyes.
文摘Purpose: To examine the relationship between retinal nerve fiber layer (RNFL) measurements obtained using scanning laser polarimetry with variable corneal compensation and corneal thickness measurements in ocular hypertension (OHT) patients. Design: Observational cross- sectional study. Subjects: The study included 1 eye each from44 OHT patients and48 healthy subjects, all of similar age. All subjects had normal optic discs and normal standard automated perimetry (SAP) visual fields. Ocular hypertension patients had intraocular pressure (IOP) measurements higher than 22 mmHg. Methods: All patients underwent imagingwith the GDx VCC (Laser Diagnostic Technologies, Inc., San Diego, CA) scanning laser polarimeter. We examined the relationship between GDx VCC RNFL measurements and central corneal thickness, a risk factor for development of visual field loss among OHT patients. We also examined the relationship of GDx VCC measurements and age, IOP, SAP pattern standard deviation, and vertical cup- todisc ratio. Main Outcome Measures: Central corneal thickness (CCT) and GDx VCC RNFL thickness parameters. Results: Central corneal thickness measurements in OHT patients were significantly higher than those in healthy subjects (575± 30 μ m vs.555± 32 μ m; P=0.002). Higher GDx VCC parameter nerve fiber indicator (NFI) scores, indicating thinner RNFL, were correlated significantly with thinner CCT measurements in OHT patients (r=- 0.502; P=0.001). Ocular hypertension patients with thinner corneas (n=22; mean CCT,553± 21 μ m)- had significantly higher NFI scores than OHT patients with thicker corneas (n=22; mean CCT,598± 18 μ m) and healthy control subjects (NFI mean± standard deviation, 26.9± 9.5, 20.7± 9.8, and 19.7± 7.0, respectively; P=0.004, analysis of variance). The NFI values were not significantly different between OHT patients with thicker corneas and healthy subjects. In multivariate analysis, only age and CCT measurement were associated significantly with GDx VCC RNFL measurements in OHT eyes. Conclusions: Ocular hypertension patients with thinner corneas had significantly thinner RNFL than OHT patients with thicker corneas and healthy control subjects. These findings support the notion thatRNFL defects as assessed by the GDx VCC may represent early glaucomatous damage in OHT eyes.
文摘Purpose: To report the use of argon laser peripheral iridoplasty in the treatment of plateau- like iris configuration as a result of iris and ciliary body cysts. Design: Case report. Methods: A43- year- old male with plateau iris syndrome was demonstrated by high frequency ultrasound biomicroscopy (UBM), to have numerous iris and ciliary body cysts. Bilateral argon laser peripheral iridoplasty was performed. Results: Argon laser iridoplasty opened the drainage angle in both eyes. Conclusion: Argon laser iridoplasty is an effective and safe treatment for plateau iris syndrome and may also prove valuable in the treatment of plateau- like iris configuration resulting from iridociliary cysts.
