Hepatosplanchnic circulation receives almost half of cardiac output and is essential to physiologic homeostasis.Liver cirrhosis is estimated to affect up to 1% of populations worldwide,including 1.5% to 3.3% of intens...Hepatosplanchnic circulation receives almost half of cardiac output and is essential to physiologic homeostasis.Liver cirrhosis is estimated to affect up to 1% of populations worldwide,including 1.5% to 3.3% of intensive care unit patients.Cirrhosis leads to hepatosplanchnic circulatory abnormalities and end-organ damage.Sepsis and cirrhosis result in similar circulatory changes and resultant multi-organ dysfunction.This review provides an overview of thehepatosplanchnic circulation in the healthy state and in cirrhosis,examines the signaling pathways that may play a role in the physiology of cirrhosis,discusses the physiology common to cirrhosis and sepsis,and reviews important issues in management.展开更多
文摘Hepatosplanchnic circulation receives almost half of cardiac output and is essential to physiologic homeostasis.Liver cirrhosis is estimated to affect up to 1% of populations worldwide,including 1.5% to 3.3% of intensive care unit patients.Cirrhosis leads to hepatosplanchnic circulatory abnormalities and end-organ damage.Sepsis and cirrhosis result in similar circulatory changes and resultant multi-organ dysfunction.This review provides an overview of thehepatosplanchnic circulation in the healthy state and in cirrhosis,examines the signaling pathways that may play a role in the physiology of cirrhosis,discusses the physiology common to cirrhosis and sepsis,and reviews important issues in management.
