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Local effect of celecoxib on peripheral nerve repair com- bined with silicone tubulization in rat 被引量:2
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作者 Rahim Mohammadi Keyvan Amini +1 位作者 Alireza Yousefi mehdi abdollahi-pirbazari 《Chinese Journal of Traumatology》 CAS CSCD 2013年第5期265-271,共7页
Objective: To assess local effect of celecoxib on nerve regeneration in a rat sciatic nerve transec- tion model. Methods: Forty-five male healthy white Wistar rats were randomly divided into three experimental grou... Objective: To assess local effect of celecoxib on nerve regeneration in a rat sciatic nerve transec- tion model. Methods: Forty-five male healthy white Wistar rats were randomly divided into three experimental groups (n= 15 for each): sham-operation (SHAM), control (SIL) and celecoxib treated (SIL/CLX) groups. In SHAM group after anesthesia left sciatic nerve was exposed and after homeo- stasis muscle was sutured. In SIL group the left sciatic nerve was exposed in the same way and transected proximal to tibioperoneal bifurcation leaving a 10 mm gap. Proximal and distal stumps were each inserted into a silicone tube and filled with 10 gl phosphate buffered solution. In SIL/CLX group defect was bridged using a silicone tube filled with 10 μl celecoxib (0.1 g/L). Results: Functional study and gastrocnemius muscle mass confirmed faster and better recovery of regenerated axons in SIL/CLX than in SIL group (P〈0.05). Morphometric indices of regenerated fibers showed number and diameter of the myelinated fibers in SIL/CLX were significantly greater than those in control group. In immunohistochemistry, lo- cation of reactions to S-100 in SIL/CLX was clearly more positive than that in SIL group. Conclusion: Response to local treatment ofcelecoxib demonstrates that it influences and improves functional re- covery of peripheral nerve regeneration. 展开更多
关键词 Peripheral nerve Sciatic nerve CELECOXIB Nerve regeneration
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