This report describes a new three‐component strategy for the regioselective synthesis of a series of tri‐substituted pyridazines via a 1,4‐diazabicyclo[2.2.2]octane （DABCO）‐catalyzed condensation of propiophenon...This report describes a new three‐component strategy for the regioselective synthesis of a series of tri‐substituted pyridazines via a 1,4‐diazabicyclo[2.2.2]octane （DABCO）‐catalyzed condensation of propiophenones, arylglyoxalmonohydrates and hydrazine hydrate in water. This method provides a green and convenient one‐pot route toward a diverse set of 3,6‐diaryl‐4‐methylpyridazines bearing various aryl substituents. This procedure is highly regioselective, operationally simple, uses water as a safe, environmentally friendly solvent, and DABCO as a green base‐organocatalyst, and affords good to excellent yields of products.展开更多
基金supported by the Research Council of Payame Noor University
文摘This report describes a new three‐component strategy for the regioselective synthesis of a series of tri‐substituted pyridazines via a 1,4‐diazabicyclo[2.2.2]octane （DABCO）‐catalyzed condensation of propiophenones, arylglyoxalmonohydrates and hydrazine hydrate in water. This method provides a green and convenient one‐pot route toward a diverse set of 3,6‐diaryl‐4‐methylpyridazines bearing various aryl substituents. This procedure is highly regioselective, operationally simple, uses water as a safe, environmentally friendly solvent, and DABCO as a green base‐organocatalyst, and affords good to excellent yields of products.
