Background： The purpose of this study was to analyze the effects of all clinical characteristics on the overall survival time, in order to provide a basis for determining the prognostic factor of patients with pancre...Background： The purpose of this study was to analyze the effects of all clinical characteristics on the overall survival time, in order to provide a basis for determining the prognostic factor of patients with pancreatic cancer. Methods： A total of 103 pancreatic cancer patients were admitted to the Department of Radiotherapy and Chemotherapy of the Ruijin Hospital, Shanghai Jiaotong University School of Medicine, between January 2002 and December 2012. There were 68 men and 35 women; the median age was 62 years. Diagnoses of pancreatic cancer in all patients were confirmed by histopathology, cytology, or clinical diagnosis. The Kaplan-Meier method was performed to calculate the overall survival rate. The log-rank method was used to examine the univariate analysis. The Cox regression model was performed for multivariate analysis. Results： The median survival time was 293 days, the 1-, 2-, and 3-year survival rates were 27.18%, 5.83%, and 1.94%, respectively. Cox regression analysis revealed that age （P=0.015）, Karnofsky performance status （PS） （P=0.002）, surgical types （P〈0.001）, and platelet counts （P〈0.001） were independent prognostic factors affecting the overall survival of patients with pancreatic cancer. Conclusions＂ Pancreatic cancer had a poor prognosis, the general physical condition, age, the availability of radical surgery, and platelet counts were factors influencing the overall survival of patients with pancreatic cancer.展开更多
Potassium metal battery is a promising alternative to Li-ion battery for large-scale energy storage due to the abundant potassium resources and high energy density.However,it suffers from rapid capacity fading and saf...Potassium metal battery is a promising alternative to Li-ion battery for large-scale energy storage due to the abundant potassium resources and high energy density.However,it suffers from rapid capacity fading and safety issues due to the uncontrolled dendrite growth.Herein,we design a fluorine-free ultra-low concentration electrolyte(ULCE)with the super bulky[BPh_(4)]^(−) anions for stable potassium metal battery.In this special electrolyte,the migration rate of K+in the electrolyte is about six times faster than that of the[BPh_(4)]^(−) anions because of the super bulky structure of the[BPh_(4)]^(−) anions,thus resulting in a high K^(+)transference number of 0.76.This high transference number can effectively make up for the deficiency of K^(+)in ULCE for ensuring the normal operation of the potassium metal battery.In addition,the improved transference number can also promote the uniform distribution of K^(+)flux on the surface of the K metal anode,resulting in uniform K deposition.As a result,this electrolyte achieves a high K plating/stripping Coulombic efficiency of 92.6%over 200 cycles and a stable discharging/charging for 100 cycles under the full battery configuration(K used as the anode and perylene-3,4,9,10-tetracarboxylic dianhydride used as the cathode).展开更多
文摘Background： The purpose of this study was to analyze the effects of all clinical characteristics on the overall survival time, in order to provide a basis for determining the prognostic factor of patients with pancreatic cancer. Methods： A total of 103 pancreatic cancer patients were admitted to the Department of Radiotherapy and Chemotherapy of the Ruijin Hospital, Shanghai Jiaotong University School of Medicine, between January 2002 and December 2012. There were 68 men and 35 women; the median age was 62 years. Diagnoses of pancreatic cancer in all patients were confirmed by histopathology, cytology, or clinical diagnosis. The Kaplan-Meier method was performed to calculate the overall survival rate. The log-rank method was used to examine the univariate analysis. The Cox regression model was performed for multivariate analysis. Results： The median survival time was 293 days, the 1-, 2-, and 3-year survival rates were 27.18%, 5.83%, and 1.94%, respectively. Cox regression analysis revealed that age （P=0.015）, Karnofsky performance status （PS） （P=0.002）, surgical types （P〈0.001）, and platelet counts （P〈0.001） were independent prognostic factors affecting the overall survival of patients with pancreatic cancer. Conclusions＂ Pancreatic cancer had a poor prognosis, the general physical condition, age, the availability of radical surgery, and platelet counts were factors influencing the overall survival of patients with pancreatic cancer.
基金supported by the National Natural Science Foundation of China(Nos.21975124 and 52173173)supported by 21C Innovation Laboratory,Contemporary Amperex Technology Ltd(No.21C-OP-202008).
文摘Potassium metal battery is a promising alternative to Li-ion battery for large-scale energy storage due to the abundant potassium resources and high energy density.However,it suffers from rapid capacity fading and safety issues due to the uncontrolled dendrite growth.Herein,we design a fluorine-free ultra-low concentration electrolyte(ULCE)with the super bulky[BPh_(4)]^(−) anions for stable potassium metal battery.In this special electrolyte,the migration rate of K+in the electrolyte is about six times faster than that of the[BPh_(4)]^(−) anions because of the super bulky structure of the[BPh_(4)]^(−) anions,thus resulting in a high K^(+)transference number of 0.76.This high transference number can effectively make up for the deficiency of K^(+)in ULCE for ensuring the normal operation of the potassium metal battery.In addition,the improved transference number can also promote the uniform distribution of K^(+)flux on the surface of the K metal anode,resulting in uniform K deposition.As a result,this electrolyte achieves a high K plating/stripping Coulombic efficiency of 92.6%over 200 cycles and a stable discharging/charging for 100 cycles under the full battery configuration(K used as the anode and perylene-3,4,9,10-tetracarboxylic dianhydride used as the cathode).
