近年来,美丽乡村建设深受政府部门与大量学者的广泛关注。文章以中国知网中2004—2022年关于我国美丽乡村研究的中文核心期刊论文为研究数据,利用Cite Space 6.1.R3进行可视化分析,通过相应的知识图谱,梳理出研究热点现状,并预测出未来...近年来,美丽乡村建设深受政府部门与大量学者的广泛关注。文章以中国知网中2004—2022年关于我国美丽乡村研究的中文核心期刊论文为研究数据,利用Cite Space 6.1.R3进行可视化分析,通过相应的知识图谱,梳理出研究热点现状,并预测出未来的研究方向,以期为我国美丽乡村研究和发展提供指导。展开更多
AIM:To explore the relationship of clinicopathological features and the distribution of neutrophils in the t umor mic roenvironment wi t h t he prognosis of cholangiocarcinoma.METHODS:Two hundred and fifty-four formal...AIM:To explore the relationship of clinicopathological features and the distribution of neutrophils in the t umor mic roenvironment wi t h t he prognosis of cholangiocarcinoma.METHODS:Two hundred and fifty-four formalin-fixed and paraffin embedded tissue blocks were analyzed, including tissues from cholangiocarcinoma(n = 254), and tumor adjacent tissues(n = 238).Tissue sections were stained for CD15 using immunohistochemical staining.CD15 expression was detected to identify the distribution of neutrophils in the local tumor microenvironment.The neutrophil density of the tumor tissues and the adjacent tumor tissues was detected to reflect their inflammatory status.Clinical data and follow-up information of cholangiocarcinoma patients who underwent surgery from January 2004 to December 2010 were analyzed retrospectively.The relationship between clinicopathological features and the distribution of neutrophils with prognosis of the patients were analyzed.RESULTS:The positive expression level of CD15 was only significantly related to the TNM stage.CD15 expression was higher in tumor tissues than in adjacent tissues(73.6% vs 54.6%), with significant differences.Patients with high expression of CD15 had significantly shorter overall survival(OS) than those with low expression of CD15(median overall survival time 39.77 mo vs 16.87 mo, P = 0.008).Patients with high CD15 expression had significantly shorter disease free survival time(DFS) than those with low expression of CD15(median DFS 38.27 mo vs 16.83 mo, P = 0.029).COX multivariate analysis indicated that high CD15 expression in tumor tissues was an independent risk factor for predicting OS for patients with cholangiocarcinoma [P = 0.012, relative risk(RR) = 1.601], but it was not an independent risk factor for predicting DFS(P = 0.073, RR = 1.462).CONCLUSION:Patients with high CD15 expression in cancer tissues had shorter DFS and OS.High expression of CD15 is an independent risk factor for OS.展开更多
In recent years, many methods have been used to find the exact solutions of nonlinear partial differential equations. One of them is called the first integral method, which is based on the ring theory of commutative a...In recent years, many methods have been used to find the exact solutions of nonlinear partial differential equations. One of them is called the first integral method, which is based on the ring theory of commutative algebra. In this paper, exact travelling wave solutions of the Non-Boussinesq wavepacket model and the (2 + 1)-dimensional Zoomeron equation are studied by using the first integral method. From the solving process and results, the first integral method has the characteristics of simplicity, directness and effectiveness about solving the exact travelling wave solutions of nonlinear partial differential equations. In other words, tedious calculations can be avoided by Maple software;the solutions of more accurate and richer travelling wave solutions are obtained. Therefore, this method is an effective method for solving exact solutions of nonlinear partial differential equations.展开更多
Objective:To investigate the effects of Bortezomib and Dexamethasone combination on treating senile multiple myeloma and influence on immune suppressed factors and immune cell levels.Methods:A total of 80 cases of pat...Objective:To investigate the effects of Bortezomib and Dexamethasone combination on treating senile multiple myeloma and influence on immune suppressed factors and immune cell levels.Methods:A total of 80 cases of patients with multiple myeloma treated in our hospital from Oct 2013 to Jul 2015 were selected as investigate subjects. They were randomly divided to be observation group consisted of 43 cases and control group consisted of 37 cases. For observation group, treatment of Bortezomib and Dexamethasone combination was provided. For control group, Vincristine + Epirubicin + Dexamethasone treatment was provided. After three courses, effects on two groups of patients were compared, and immune suppressed factors and immune cell levels before and after treatment in different periods were compared.Results:After three courses of treatment, the total effective rate in observation group was significantly higher than control group. Before treatment, IL-6, IL-17, TGF-β, CD3+CD4+, CD3+CD8+ and CD3+CD4+/CD3+CD8+ between the two group of patients were compared, no significant difference showed;After treatment for 6 weeks, IL-6, IL-17 levels in observation group were significantly decreased comparing with the same group before treatment;After treatment for 12 weeks, IL-6, IL-17 and TGF-β levels in observation group were significantly decreased comparing with the same group before treatment;After treatment, IL-6, IL-17 levels in observation group were significantly lower than control group at the same phase. After treatment for 12 weeks, CD3+CD4+, CD3+CD4+/CD3+CD8+ in observation group were significantly higher than the same group before treatment, and significantly higher than control group at the same phase;CD3+CD8+ in observation group was significantly lower than the same group before treatment, and significantly lower than control group at the same phase. Conclusion:Compared with Vincristine + Epirubicin + Dexamethasone treatment, Bortezomib and Dexamethasone combination on treating senile multiple myeloma had more significant effects, which deserves further clinical researches.展开更多
The special kind of (G’/G)-expansion method and the new mapping method are easy and significant mathematical methods. In this paper, exact travelling wave solutions of the higher order dispersive Cubic-quintic nonlin...The special kind of (G’/G)-expansion method and the new mapping method are easy and significant mathematical methods. In this paper, exact travelling wave solutions of the higher order dispersive Cubic-quintic nonlinear Schrödinger equation and the generalized nonlinear Schrödinger equation are studied by using the two methods. Finally, the solitary wave solutions, singular soliton solutions, bright and dark soliton solutions and periodic solutions of the two nonlinear Schrödinger equations are obtained. The results show that this method is effective for solving exact solutions of nonlinear partial differential equations.展开更多
Scale insects comprise a diverse group of insects within superfamily Coccoidea in the suborder Sternorrhyncha,many of them are important pests of economic crops.The advent in next-generation sequencing(NGS)technologie...Scale insects comprise a diverse group of insects within superfamily Coccoidea in the suborder Sternorrhyncha,many of them are important pests of economic crops.The advent in next-generation sequencing(NGS)technologies has revolutionized conventional phylogenomic researches,causing a rapid accumulation of sequenced insect mitochondrial genomes.However,there have been few studies on the mitochondrial genome of diverse scale insect groups.By using NGS methods,the complete mitochondrial genome of Nipponaclerda biwakoensis was obtained in this study,representing the first mtDNA of the family Aclerdidae.The whole mitochondrial genome is 16,654 bp in length with an A+T content of 81.3%,including 13 protein-coding genes(PCGs),2 ribosomal RNAs,17 transfer RNAs and a control region.All PCGs begin with typical ATN codons and use standard TAA as their termination codons,except nad1 gene stopping with TAG.Meanwhile,this mitochondrial genome shows a unique gene rearrangement with a long fragment(trnP-trnC-trnI-nad2-trnY-trnT)insertion in the conserved region nad6-cob,which is novel to Hemiptera,even Insecta.The phylogeny reconstruction of Sternorrhyncha based on 13 PCGs and 2 rRNAs under Bayesian Inference method support a robust topology that Aleyrodoidea is the earliest branch of Sternorrhyncha,with Psylloidea as the sister group of the(Aphidoidea+Coccoidea)clade.展开更多
Summary What is already known about this topic?Symptoms of malnutrition including anemia,stunting,wasting,and being underweight among children remained one of the major public health problems in poorer areas in China....Summary What is already known about this topic?Symptoms of malnutrition including anemia,stunting,wasting,and being underweight among children remained one of the major public health problems in poorer areas in China.More research is needed to guide interventions to improve nutrition and health among children in low-income regions.展开更多
文摘AIM:To explore the relationship of clinicopathological features and the distribution of neutrophils in the t umor mic roenvironment wi t h t he prognosis of cholangiocarcinoma.METHODS:Two hundred and fifty-four formalin-fixed and paraffin embedded tissue blocks were analyzed, including tissues from cholangiocarcinoma(n = 254), and tumor adjacent tissues(n = 238).Tissue sections were stained for CD15 using immunohistochemical staining.CD15 expression was detected to identify the distribution of neutrophils in the local tumor microenvironment.The neutrophil density of the tumor tissues and the adjacent tumor tissues was detected to reflect their inflammatory status.Clinical data and follow-up information of cholangiocarcinoma patients who underwent surgery from January 2004 to December 2010 were analyzed retrospectively.The relationship between clinicopathological features and the distribution of neutrophils with prognosis of the patients were analyzed.RESULTS:The positive expression level of CD15 was only significantly related to the TNM stage.CD15 expression was higher in tumor tissues than in adjacent tissues(73.6% vs 54.6%), with significant differences.Patients with high expression of CD15 had significantly shorter overall survival(OS) than those with low expression of CD15(median overall survival time 39.77 mo vs 16.87 mo, P = 0.008).Patients with high CD15 expression had significantly shorter disease free survival time(DFS) than those with low expression of CD15(median DFS 38.27 mo vs 16.83 mo, P = 0.029).COX multivariate analysis indicated that high CD15 expression in tumor tissues was an independent risk factor for predicting OS for patients with cholangiocarcinoma [P = 0.012, relative risk(RR) = 1.601], but it was not an independent risk factor for predicting DFS(P = 0.073, RR = 1.462).CONCLUSION:Patients with high CD15 expression in cancer tissues had shorter DFS and OS.High expression of CD15 is an independent risk factor for OS.
文摘In recent years, many methods have been used to find the exact solutions of nonlinear partial differential equations. One of them is called the first integral method, which is based on the ring theory of commutative algebra. In this paper, exact travelling wave solutions of the Non-Boussinesq wavepacket model and the (2 + 1)-dimensional Zoomeron equation are studied by using the first integral method. From the solving process and results, the first integral method has the characteristics of simplicity, directness and effectiveness about solving the exact travelling wave solutions of nonlinear partial differential equations. In other words, tedious calculations can be avoided by Maple software;the solutions of more accurate and richer travelling wave solutions are obtained. Therefore, this method is an effective method for solving exact solutions of nonlinear partial differential equations.
文摘Objective:To investigate the effects of Bortezomib and Dexamethasone combination on treating senile multiple myeloma and influence on immune suppressed factors and immune cell levels.Methods:A total of 80 cases of patients with multiple myeloma treated in our hospital from Oct 2013 to Jul 2015 were selected as investigate subjects. They were randomly divided to be observation group consisted of 43 cases and control group consisted of 37 cases. For observation group, treatment of Bortezomib and Dexamethasone combination was provided. For control group, Vincristine + Epirubicin + Dexamethasone treatment was provided. After three courses, effects on two groups of patients were compared, and immune suppressed factors and immune cell levels before and after treatment in different periods were compared.Results:After three courses of treatment, the total effective rate in observation group was significantly higher than control group. Before treatment, IL-6, IL-17, TGF-β, CD3+CD4+, CD3+CD8+ and CD3+CD4+/CD3+CD8+ between the two group of patients were compared, no significant difference showed;After treatment for 6 weeks, IL-6, IL-17 levels in observation group were significantly decreased comparing with the same group before treatment;After treatment for 12 weeks, IL-6, IL-17 and TGF-β levels in observation group were significantly decreased comparing with the same group before treatment;After treatment, IL-6, IL-17 levels in observation group were significantly lower than control group at the same phase. After treatment for 12 weeks, CD3+CD4+, CD3+CD4+/CD3+CD8+ in observation group were significantly higher than the same group before treatment, and significantly higher than control group at the same phase;CD3+CD8+ in observation group was significantly lower than the same group before treatment, and significantly lower than control group at the same phase. Conclusion:Compared with Vincristine + Epirubicin + Dexamethasone treatment, Bortezomib and Dexamethasone combination on treating senile multiple myeloma had more significant effects, which deserves further clinical researches.
文摘The special kind of (G’/G)-expansion method and the new mapping method are easy and significant mathematical methods. In this paper, exact travelling wave solutions of the higher order dispersive Cubic-quintic nonlinear Schrödinger equation and the generalized nonlinear Schrödinger equation are studied by using the two methods. Finally, the solitary wave solutions, singular soliton solutions, bright and dark soliton solutions and periodic solutions of the two nonlinear Schrödinger equations are obtained. The results show that this method is effective for solving exact solutions of nonlinear partial differential equations.
基金supported by the National Key R&D Program of China(2018YFA0703400)the National Natural Science Foundation of China(52073245,52002118,52202071,52202049)+1 种基金Macao Youth Scholars Program(AM2021015)the Postdoctoral Science Preferential Funding of Hebei Province(B2022003021,B2021005001)。
基金supported by the National Key R&D Program of China(2021YFD1400200)National Natural Science Foundation of China(31801998,31772488,32070465)Yunnan Basic Research Fund for Youth(2019FD072).
文摘Scale insects comprise a diverse group of insects within superfamily Coccoidea in the suborder Sternorrhyncha,many of them are important pests of economic crops.The advent in next-generation sequencing(NGS)technologies has revolutionized conventional phylogenomic researches,causing a rapid accumulation of sequenced insect mitochondrial genomes.However,there have been few studies on the mitochondrial genome of diverse scale insect groups.By using NGS methods,the complete mitochondrial genome of Nipponaclerda biwakoensis was obtained in this study,representing the first mtDNA of the family Aclerdidae.The whole mitochondrial genome is 16,654 bp in length with an A+T content of 81.3%,including 13 protein-coding genes(PCGs),2 ribosomal RNAs,17 transfer RNAs and a control region.All PCGs begin with typical ATN codons and use standard TAA as their termination codons,except nad1 gene stopping with TAG.Meanwhile,this mitochondrial genome shows a unique gene rearrangement with a long fragment(trnP-trnC-trnI-nad2-trnY-trnT)insertion in the conserved region nad6-cob,which is novel to Hemiptera,even Insecta.The phylogeny reconstruction of Sternorrhyncha based on 13 PCGs and 2 rRNAs under Bayesian Inference method support a robust topology that Aleyrodoidea is the earliest branch of Sternorrhyncha,with Psylloidea as the sister group of the(Aphidoidea+Coccoidea)clade.
文摘Summary What is already known about this topic?Symptoms of malnutrition including anemia,stunting,wasting,and being underweight among children remained one of the major public health problems in poorer areas in China.More research is needed to guide interventions to improve nutrition and health among children in low-income regions.
