Induced magneto-conductivity in a two-nodeWeyl semimetal under Gaussian random disorder

Measuring the magneto-conductivity induced from impurities may help determine the impurity distribution and reveal the structure of a Weyl semimetal sample.To verify this,we utilize the Gaussian random disorder to simulate charged impurities in a two-node Weyl semimetal model and investigate the impact of charged impurities on magneto-conductivity in Weyl semimetals.We first compute the longitudinal magnetic conductivity and find that it is positive and increases proportionally with the parameter governing the Gaussian distribution of charged impurities,suggesting the presence of negative longitudinal magneto-resistivity.Then we consider both the intra-valley and inter-valley scattering processes to calculate the induced transverse magneto-conductivity in the model.Our findings indicate that both inter-valley and intravalley scattering processes play important roles in the transverse magneto-conductivity.The locations of Weyl nodes can also be determined by magneto-conductivity measurements.This is possible if the magnetic field strength and the density of charged impurities are known.Alternatively,the measurement of magnetic conductivity may reveal the distribution of charged impurities in a given sample once the locations of the Weyl nodes have been determined.These findings can aid in detecting the structure of a Weyl semimetal sample,enhancing comprehension of magnetotransport in Weyl semimetals and promoting the development of valley electronics.

Analysis of the role of dihydromyricetin derived from vine tea(Ampelopsis grossedentata)on multiple myeloma by activating STAT1/RIG-I axis

Multiple myeloma(MM)is a plasma cell malignancy and remains incurable as it lacks effective curative approaches;thus,novel therapeutic strategies are desperately needed.The study aimed to explore the therapeutic role of dihydromyricetin(DHM)in MM and explore its mechanisms.Human MM and normal plasma samples,human MM cell lines,and normal plasma cells were used for in vitro experiments.Cell counting kit-8(CCK-8),flow cytometry,and trans-well assays were performed for the assessment of cell viability,apoptosis,migration,and invasion,respectively.Quantitative real-time polymerase chain reaction(qRT-PCR)was employed to assess the mRNA expression of signal transducer and activator of transcription 1(STAT1)and retinoic acid-inducible gene I(RIG-I).Western blotting was employed to assess E-cadherin,N-cadherin,signal transducer,STAT1,p-STAT1,and RIG-I protein expression.A tumor xenograft model was used for in vivo experiments.Here,dihydromyricetin(DHM)dose-dependently restrained viability,apoptosis,migration,and invasion,and facilitated apoptosis of U266 cells.After DHM treatment,the Ecadherin level was increased and the N-cadherin level was decreased in U266 and RPMI-8226 cells,suggesting the inhibitory effects of DHM on epithelial-mesenchymal transition(EMT)in MM.Besides,the levels of p-STAT1/STAT1 and RIG-I were down-regulated in MM.However,the STAT1 inhibitor fludarabine undid the suppressive effect of DMH on the malignant characteristics of U266 cells.Also,DHM inhibited MM tumor growth and EMT,and activated STAT1/RIG-I pathway in vivo.Collectively,this study first revealed that DHM can restrain EMT and tumor growth in MM by activating STAT1/RIG-I signaling,which provides a novel drug for the treatment of MM.

Meigs syndrome with pleural effusion as initial manifestation:A case report

BACKGROUND Meigs syndrome is a rare neoplastic disease characterized by the triad of benign solid ovarian tumor,ascites,and pleural effusion.In postmenopausal women with pleural effusions,ascites,elevated CA-125 level,and pelvic masses,the probability of disseminated disease is high.Nevertheless,the final diagnosis is based on its histopathologic features following surgical removal of a mass lesion.Here we describe a case of Meigs syndrome with pleural effusion as the initial manifestation.CASE SUMMARY A 52-year-old woman presented with a 2-mo history of dry cough and oppression in the chest and was admitted to our hospital due to recurrent pleural effusion and gradual worsening of dyspnea that had occurred over the previous month.Two months before admission,the patient underwent repeated chest drainage and empirical anti-tuberculosis treatment.However,the pleural fluid accumulation persisted,and the patient began to experience dyspnea on exertion leading to admission.A computed tomography scan of the chest,abdominal ultrasound,and magnetic resonance imaging confirmed the presence of right-sided pleural effusion and ascites with a right ovarian mass.Serum tumor markers showed raised CA-125.With a suspicion of a malignant tumor,the patient underwent laparoscopic excision of the ovarian mass and the final pathology was consistent with an ovarian fibrothecoma.On the seventh day postoperation,the patient had resolution of the right-sided pleural effusion.CONCLUSION Despite the relatively high risk of malignancy when an ovarian mass associated with hydrothorax is found in a patient with elevated serum levels of CA-125,clinicians should be aware about rare benign syndromes,like Meigs,for which surgery remains the preferred treatment.

Serum Concentrations of Angiotensin, C-Reactive Protein, Interleukin-8, and Tumor Necrosis Factor-α in Train Driver Population

Train drivers are engaged in high-stress job. It may induce sleep, fatigue, and alertness loss at work, and endanger public safety. It’s unclear that cytokines of train driver would be influenced by their job. The research considers the hypothesis that stressful professions, such as train driver, influence the body’s immune system through the long-time and high-pressure working, and change production of neuro-immune factors. Using enzyme linked immunosorbent assay (ELISA), several neuro-immune factors were assayed among train drivers (N = 82) and health blood donors (N = 80) enrolled in the Yunnan Collaborative Innovation Center for Public Health and Disease Control. The concentrations of angiotensin, C-reactive protein (CRP), interleukin-8 (IL-8), and tumor necrosis factor-alpha (TNF-α) were determined. Kruskal-Wallis test and Dunn’s multiple comparisons test were performed for overall comparison between groups and for pairwise comparison, respectively. Statistical significance level was set at P < 0.05. The profession of train driving was not associated with significant increases or decreases in the systemic levels of inflammatory (CRP, IL-8, and TNF-α), but it was associated with the high expression of angiotensin in vivo. These findings suggest that the job of train driving may not be associated with significant alterations in systemic immune condition, but arouse the level of angiotensin.

PD-L1和PD-1在T4期结直肠癌组织及周围转移淋巴结中的表达情况及与预后相关性研究

目的探讨程序性死亡受体1(PD-1)和程序性死亡配体1(PD-L1)在T4期结直肠癌组织及周围转移淋巴结中的表达情况及与预后相关性。方法选取2017年12月至2021年5月常州市第七人民医院收治的T4期结直肠癌患者80例,采取免疫组化法对结直肠癌组织及周围转移淋巴结中的PD-L1、PD-1表达进行检测,比较PD-L1、PD-1表达与淋巴结转移、年龄、肿瘤最大径、组织学分级及预后的关系。结果PD-L1、PD-1高表达患者总生存期和无进展生存期表达率与PD-L1、PD-1中度表达和低表达患者比较,差异有统计学意义(P<0.05);T4期结直肠癌组织及周围转移淋巴结患者中检测到54例PD-L1表达,其中高表达38例(70.37%)、中度表达10例(18.52%)、低表达6例(11.11%),差异有统计学意义(P<0.05);T4期结直肠癌组织及周围转移淋巴结患者中检测到54例PD-1表达,其中高表达38例(70.37%)、中度表达10例(18.52%)、低表达6例(11.11%),差异有统计学意义(P<0.05)。结论PD-LI、PD-1在结直肠癌组织中表达明显上升,且淋巴结转移及预后生存关系密切。

胰岛素泵对2型糖尿病合并颈动脉粥样硬化患者糖脂代谢及氧化应激的影响

目的探讨胰岛素泵治疗对2型糖尿病合并颈动脉粥样硬化患者的血糖、血脂水平及同型半胱氨酸(homocysteine,Hcy)的影响。方法选取2015年1月至2018年12月安徽省合肥市第三人民医院收治的96例2型糖尿病合并颈动脉粥样硬化患者,按照随机数表法分为对照组(48例)和试验组(48例)。对照组患者给予皮下注射门冬胰岛素30注射液联合二甲双胍肠溶片治疗,试验组患者给予胰岛素泵皮下持续输注门冬胰岛素注射液。比较两组患者治疗前后血糖、胰岛素抵抗指数(insulin resistance index,IRI)、血脂和Hcy水平变化。结果两组患者治疗后空腹血糖、餐后2h血糖和糖化血红蛋白较治疗前降低(P<0.05);试验组患者治疗后空腹血糖、餐后2h血糖和糖化血红蛋白低于对照组(P<0.05)。两组患者治疗后IRI较治疗前降低(P<0.05);试验组患者治疗后IRI低于对照组(P<0.05)。两组患者治疗后高密度脂蛋白胆固醇水平较治疗前升高,而低密度脂蛋白胆固醇、甘油三酯和总胆固醇水平较治疗前降低(P<0.05);试验组患者治疗后高密度脂蛋白胆固醇水平高于对照组,而低密度脂蛋白胆固醇、甘油三酯和总胆固醇水平低于对照组(P<0.05)。两组患者治疗后Hcy水平较治疗前降低(P<0.05);试验组患者治疗后Hcy水平低于对照组(P<0.05)。结论胰岛素泵治疗可明显降低2型糖尿病合并颈动脉粥样硬化患者的血糖水平,改善患者血脂和Hcy水平,值得临床借鉴。

门冬胰岛素30联合二甲双胍治疗T2DM的临床疗效及对患者血糖及血脂水平影响的研究

目的探讨和分析门冬胰岛素30联合二甲双胍治疗T2DM的临床疗效及对患者血糖和血脂水平的影响。方法选取2015年1月至2017年12月期间于我院接受治疗的104例T2DM患者作为此次研究对象,在患者知情并自愿参与的原则下,双盲法随机分为对照组(52例)和研究组(52例)。其中对照组给予二甲双胍治疗,研究组在此基础上再联合门冬胰岛素30治疗,持续治疗12w后,对两组患者血糖、血脂水平及生存质量(QOL-BRE)进行对比分析。结果治疗后,两组患者FPG、2h PG和Hb A1c水平较治疗前均呈显著性下降(P<0.05),且研究组下降水平与对照组相比,差异具有统计学意义(P<0.05);与治疗前相比,治疗后两组患者的TC、TG和LDL-C下降,HDL-C上升,差异具有统计学意义(P<0.05),且治疗后研究组血脂水平较对照组,差异同样具有统计学意义(P<0.05);两组患者治疗后的QOL-BREF评分均显著高于治疗前(P<0.05),且研究组QOL-BREF评分较对照组,差异具有显著性差异(P<0.05)。结论门冬胰岛素30联合二甲双胍治疗T2DM能显著控制血糖、血脂水平,并提升患者生存质量,是一种值得推荐的临床联合用药方案。

Mechanism underlying carbon tetrachloride-inhibited protein synthesis in liver

AIM: To study the mechanism underlying carbon tetrachloride (CCl4)-induced alterations of protein synthesis in liver. METHODS: Male Sprague-Dawley rats were given CCl4 (1 mL/100 g body weight) and 3H-leucine incorporation. Malondialdehyde (MDA) level in the liver, in vitro response of hepatocyte nuclei nucleotide triphosphatase (NTPase) to free radicals, and nuclear export of total mRNA with 3'-poly A+ were measured respectively. Survival response of HepG2 cells to CCl4 treatment was assessed by methyl thiazolyl tetrazolium. Km and Vmax values of nuclear envelope NTPase activity in liver of rats treated with CCl4 were assayed by a double-reciprocal plot. RESULTS: The protein synthesis was inhibited while the MDA level was signif icantly increased in liver of rats treated with CCl4. In addition, CCl4 decreased the NTPase binding capacity of nuclear envelope (Km value) in cultured HepG2 cells. Moreover, in vitro ferrous radicals from Fenton's system suppressed the NTPase activity of liver nuclear envelope in a dose-dependent manner. Down-regulation of the nuclear envelope NTPase activity indicated a lower energy provision for nucleocytoplasmic transport of mRNA molecules, an evidence in CCl4-treated HepG2 cells correspondingly supported by the nuclear sequestration of poly (A)+ mRNA molecules in morphological hybridization research. CONCLUSION: Inhibition of mRNA transport, suggestive of decreased NTPase activity of the nuclear envelope, may be involved in carbon tetrachloride-inhibited protein synthesis in liver.

Spatial-spectral identication of abnormal leukocytes based on microscopic hyperspectral imaging technology

Screening and diagnosing of abnormal Leukocytes are crucial for the diagnosis of immune diseases and Acute Lymphoblastic Leukemia(ALL).As the deterioration of abnormal leukocytes is mainly due to the changes in the chromatin distribution,which signicantly affects the absorption and reflection of light,the spectral feature is proved to be important for leukocytes classication and identication.This paper proposes an accurate identication method for healthy and abnormal leukocytes based on microscopic hyperspectral imaging(HSI)technology which combines the spectral information.The segmentation of nucleus and cytoplasm is obtained by the morphological watershed algorithm.Then,the spectral features are extracted and combined with the spatial features.Based on this,the support vector machine(SVM)is applied for classication ofve types of leukocytes and abnormal leukocytes.Compared with different classication methods,the proposed method utilizes spectral features which highlight the differences between healthy leukocytes and abnormal leukocytes,improving the accuracy in the classication and identication of leukocytes.This paper only selects one subtype of ALL for test,and the proposed method can be applied for detection of other leukemia in the future.

In situ apolipoprotein E-enriched corona guides dihydroartemisinin-decorating nanoparticles towards LDLr-mediated tumor-homing chemotherapy

The therapeutic efficiency of active targeting nanoparticulate drug delivery systems(nano-DDS)is highly compromised by the plasma proteins adsorption on nanoparticles(NPs)surface,which significantly hinders cell membrane receptors to recognize the designed ligands,and provokes the off-target toxicity and rapid clearance of NPs in vivo.Herein,we report a novel dihydroartemisinin(DHA)-decorating nano-DDS that in situ specifically recruits endogenous apolipoprotein E(apoE)on the NPs surface.The apoE-anchored corona is able to prolong PLGA-PEG2000-DHA(PPD)NPs circulation capability in blood,facilitate NPs accumulating in tumor cells by the passive enhanced permeability and retention(EPR)effect and low-density lipoprotein receptor(LDLr)-mediated target transport,and ultimately improve the in vivo antitumor activity.Our findings demonstrate that the strategy of in situ regulated apoE-enriched corona ensures NPs an efficient LDLr-mediated tumor-homing chemotherapy.

非洲猪瘟形势下我国养猪业该何去何从

非洲猪瘟是由非洲猪瘟病毒感染家猪或野猪后引发的一种恶性传染病,该疫病在中国的暴发给整个养猪业造成了毁灭性的打击。然而,目前虽有报道称已经有科研单位研制出非洲猪瘟疫苗,但距离其实际应用于生产仍需要相当长的时间。中国是全球最大的猪肉生产和消费国,非洲猪瘟疫情在我国的快速传播使我国生猪产能遭受重创,直接导致猪肉供求失衡、猪肉价格翻番、猪肉市场异动。因此,文章从非洲猪瘟的传播方式、对非洲猪瘟相对有效的防控措施等方面探讨在非洲猪瘟形势下我国养猪业该如何维持产能、如何走好养殖之路。

Development of Liposome containing sodium deoxycholate to enhance oral bioavailability of itraconazole

The aim of this study was to enhance oral bioavailability of itraconazole(ITZ) by developing Liposome containing sodium deoxycholate(ITZ-Lip-NaDC). The liposome, consisting of egg yolk lecithin and sodium deoxycholate, was prepared by thin-film dispersion method.Differential Scanning Calorimetry(DSC) results indicated an amorphous state in the liposome. The physicochemical characteristics including particle size, morphology, entrapment efficiency, dissolution properties were also investigated. The performance of single-pass intestinal infusion exhibited that the transport order of intestinal segment was jejunum,duodenum, colon and ileum, and that all the segments participated in the absorption of ITZ in intestinal tract. The bioavailability study in rats showed that the AUC0-72 of the liposome was nearly 1.67-fold higher than that of commercial capsules(SPORANOX) in terms of oral administration, and the RSD of AUC0-72 of ITZ-Lip-NaD C was also decreased. Our results indicated that ITZ-Lip-NaDC liposome was facilitated to improve dissolution efficiency,augment transmembrane absorption, and then enhance the oral bioavailability of ITZ,successfully.

Polymeric nanoparticles developed by vitamin E-modified aliphatic polycarbonate polymer to promote oral absorption of oleanolic acid

Oleanolic acid (OA) exhibited good pharmacological activities in the clinical treatment of hypoglycemia, immune regulation, acute jaundice and chronic toxic hepatitis. However, the oral delivery of OA is greatly limited by its inferior water solubility and poor intestinal mucosa permeability. Herein, we developed a novel polymeric nanoparticle (NP) delivery system based on vitamin E modified aliphatic polycarbonate (mPEG-PCC-VE) to facilitate oral absorption of OA. OA encapsulated mPEG-PCC-VE NPs (OA/mPEG-PCC-VE NPs) showed uniform particle size of about 170 nm with high drug loading capability (8.9%). Furthermore, the polymeric mPEG-PCC-VE NPs, with good colloidal stability and pH-sensitive drug release characteristics, significantly enhanced the in vitro dissolution of OA in the alkaline medium. The in situ single pass intestinal perfusion (SPIP) studies performed on rats demonstrated that the OA/m PEG-PCC-VE NPs showed significantly improved permeability in the whole intestinal tract when compared to OA solution, especially for duodenum and colon. As a result, the in vivo pharmacokinetics study indicated that the bioavailability of OA/m PEG-PCC-VE NPs showed 1.5-fold higher than commercially available OA tablets. These results suggest that mPEGPCC-VE NPs are a promising platform to facilitate the oral delivery of OA.

CD34^(+)CD38^(-)subpopulation without CD123 and CD44 is responsible for LSC and correlated with imbalance of immune cell subsets in AML

Acute myeloid leukemia(AML)is regarded as a stem cell disease.However,no one unique marker is expressed on leukemia stem cells(LSC)but not on leukemic blasts nor normal hematopoietic stem cells(HSC).CD34^(+)CD38^(-)with or without CD123 or CD44 subpopulations are immunophenotypically defined as putative LSC fractions in AML.Nevertheless,markers that can be effectively and simply held responsible for the intrinsical heterogeneity of LSC is still unclear.In the present study,we examined the frequency of three different LSC subtypes(CD34^(+)CD38^(-),CD34^(+)CD38^(-)CD123^(+),CD34^(+)CD38^(-)CD44^(+))in AML at diagnosis.We then validated their prognostic significance on the relevance of spectral features for diagnostic stratification,immune status,induction therapy response,treatment effect maintenance,and long^(-)term survival.In our findings,high proportions of the above three different LSC subtypes were all significantly characterized with low complete remission(CR)rate,high relapse/refractory rate,poor overall survival(OS),frequent FLT3^(-)ITD mutation,the high level of regulatory T cells(Treg)and monocytic myeloid^(-)derived suppressor cells(M^(-)MDSC).However,there was no significant statistical difference in all kinds of other clinical performance among the three different LSC groups.It was demonstrated that CD34^(+)CD38^(-)subpopulation without CD123 and CD44 might be held responsible for LSC and correlated with an imbalance of immune cell subsets in AML.

苹果渣对马铃薯饼干品质特性的影响

采用单因素及正交实验相结合的方法,在制备马铃薯饼干的工艺中添加苹果渣来改善马铃薯饼干的坚硬质地和粗糙口感,增加其香气和风味。结果表明,马铃薯饼干的最佳配方为马铃薯全粉25%,苹果渣10%,色拉油35%,膨松剂1.6%。以上配方生产出的饼干香味纯正,品质细腻,口感优良,具有苹果清香和风味。

Macrophage CARD9 mediates cardiac injury following myocardial infarction through regulation of lipocalin 2 expression

Immune cell infiltration in response to myocyte death regulates extracellular matrix remodeling and scar formation after myocardial infarction(MI).Caspase-recruitment domain family member 9(CARD9)acts as an adapter that mediates the transduction of pro-inflammatory signaling cascades in innate immunity;however,its role in cardiac injury and repair post-MI remains unclear.We found that Card9 was one of the most upregulated Card genes in the ischemic myocardium of mice.CARD9 expression increased considerably 1 day post-MI and declined by day 7 post-MI.Moreover,CARD9 was mainly expressed in F4/80-positive macrophages.Card9 knockout(KO)led to left ventricular function improvement and infarct scar size reduction in mice 28 days post-MI.Additionally,Card9 KO suppressed cardiomyocyte apoptosis in the border region and attenuated matrix metalloproteinase(MMP)expression.RNA sequencing revealed that Card9 KO significantly suppressed lipocalin 2(Lcn2)expression post-MI.Both LCN2 and the receptor solute carrier family 22 member 17(SL22A17)were detected in macrophages.Subsequently,we demonstrated that Card9 overexpression increased LCN2 expression,while Card9 KO inhibited necrotic cell-induced LCN2 upregulation in macrophages,likely through NF-κB.Lcn2 KO showed beneficial effects post-MI,and recombinant LCN2 diminished the protective effects of Card9 KO in vivo.Lcn2 KO reduced MMP9 post-MI,and Lcn2 overexpression increased Mmp9 expression in macrophages.Slc22a17 knockdown in macrophages reduced MMP9 release with recombinant LCN2 treatment.In conclusion,our results demonstrate that macrophage CARD9 mediates the deterioration of cardiac function and adverse remodeling post-MI via LCN2.

CPSDv0: a forest stand structure database for plantation forests in China

Forest stand structure is not only a crucial factor for regulating forest functioning but also an important indicator for sustainable forest management and ecosystem services.Although there exists a few national/global structure databases for natural forests,a country-wide synthetic structure database for plantation forests over China,the world’s largest player in plantation forests,has not been achieved.In this study,we built a country-wide synthetic stand structure database by surveying more than 600 peer-reviewed literature.The database covers tree species,mean stand age,mean tree height,stand density,canopy coverage,diameter at breast height,as well as the associated ancillary in-situ topographical and soil properties.A total of 594 pub-lished studies concerning diverse forest stand structure parameters were compiled for 46 tree species.This first synthesis for stand structure of plantation forests over China supports studies on the evolution/health of plantation forests in response to rapid climate change and intensified disturbances,and benefits country-wide sustainable forest management,future afforestation or reforestation planning.Potential users include those studying forest community dynamics,regional tree growth,ecosystem stability,and health,as well as those working with conservation and sustainable management.This dataset is freely acces-sible at http://www.doi.org/10.11922/sciencedb.j00076.00091.

Mental health, health-related quality of life, and lung function after hospital discharge in healthcare workers with severe COVID-19: a cohort study from China

Coronavirus disease 2019(COVID-19)is an acute respiratory infectious disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.It is highly contagious and can cause death in severe cases.As reported by the World Health Organization(WHO),as of 6:36 pm Central European Summer Time(CEST),12 August 2022,there had been 585950285 confirmed cases of COVID-19,including 6425422 deaths(WHO,2022).According to previous studies,healthcare workers(HCWs)have a higher risk of developing COVID-19 compared with the general community,and the severity of COVID-19 is closely related to the health-related effects after discharge(Huang et al.,2021).

Automatic marker-free registration of single tree point-cloud data based on rotating projection

Point-cloud data acquired using a terrestrial laser scanner play an important role in digital forestry research.Multiple scans are generally used to overcome occlusion effects and obtain complete tree structural information.However,the placement of artificial reflectors in a forest with complex terrain for marker-based registration is time-consuming and difficult.In this study,an automatic coarse-to-fine method for the registration of pointcloud data from multiple scans of a single tree was proposed.In coarse registration,point clouds produced by each scan are projected onto a spherical surface to generate a series of two-dimensional(2D)images,which are used to estimate the initial positions of multiple scans.Corresponding feature-point pairs are then extracted from these series of 2D images.In fine registration,point-cloud data slicing and fitting methods are used to extract corresponding central stem and branch centers for use as tie points to calculate fine transformation parameters.To evaluate the accuracy of registration results,we propose a model of error evaluation via calculating the distances between center points from corresponding branches in adjacent scans.For accurate evaluation,we conducted experiments on two simulated trees and six real-world trees.Average registration errors of the proposed method were 0.026 m around on simulated tree point clouds,and 0.049 m around on real-world tree point clouds.

PCA-U-Net based breast cancer nest segmentation from microarray(jj)hyperspectral images

The incidence of breast cancer is tending younger globally,and tumor development,clinical treatment,and prognosis are largely influenced by histopathological diagnosis.For diagnosed patients,the distinction between the cancer nests and normal tissue is the basis of breast cancer treatment.Microscopic hyperspectral imaging technology has shown its potential in auxiliary pathological examinations due to the superior imaging modality and data characteristics.This paper presents a method for cancer nest segmentation from hyperspectral images of breast cancer tissue microarray samples.The scheme combines the strengths of the U-Net neural network and unsupervised principal component analysis,which reduces the amount of calculation and improves the recognition accuracy.The experimental accuracy of cancer nest segmentation reaches 87.14%.Furthermore,a set of quantitative pathological characteristic parameters reflects the degree of breast cancer lesions from multiple angles,providing a relatively comprehensive reference for the pathologist’s diagnosis.In-depth exploration of the combined development of deep learning and microscopic hyperspectral imaging technology is worthy to promote efficient diagnosis of breast tumors and concern for human health.