Four new monoterpenoid indole alkaloids,alstrostines C-F together with thirteen known alkaloids were isolated from the leaves and twigs of Alstonia rostrata.All structures of new compounds were elucidated based on NMR...Four new monoterpenoid indole alkaloids,alstrostines C-F together with thirteen known alkaloids were isolated from the leaves and twigs of Alstonia rostrata.All structures of new compounds were elucidated based on NMR,FTIR,UV,and MS spectroscopic data.Alstrostines C-E might originate from keto-enol tautomerism of preakummicine during biogenetic pathway of akummicine.展开更多
Three new monoterpene indole alkaloids,3a-hydroxymethyl-ibogamine(1),3a-acetatemethoxyl-ibogamine(2),16a-hy-droxyl-ibogamine(3)together with six known alkaloids were isolated from the branches and leaves of Tabernaemo...Three new monoterpene indole alkaloids,3a-hydroxymethyl-ibogamine(1),3a-acetatemethoxyl-ibogamine(2),16a-hy-droxyl-ibogamine(3)together with six known alkaloids were isolated from the branches and leaves of Tabernaemontana divaricata(Apocynaceae).The structures of these alkaloids were determined by spectroscopic analyses.All isolated compounds showed no significant cytotoxicity against SGC-7901 gastric cancer,HeLa,and A-549 lung cancer cell lines(IC50>20μM).展开更多
Five new alkaloids(1–5)were isolated from the leaves and twigs of Cephalotaxus lanceolata and C.fortunei var.alpina along with 24 known alkaloids.The new structures were elucidated based on spectroscopic data includi...Five new alkaloids(1–5)were isolated from the leaves and twigs of Cephalotaxus lanceolata and C.fortunei var.alpina along with 24 known alkaloids.The new structures were elucidated based on spectroscopic data including 1D and 2D NMR,FTIR,UV and MS.These new alkaloids showed no cytotoxicity to HeLa,SGC-7901 gastric cancer,and A-549 lung cancer cell lines.展开更多
Fourteen unprecedented artificial Erythrina alkaloids were isolated from the Erythrina variegata,E.crista-galli and E.arborescens(Fabaceae).The structures of these alkaloids were determined by spectroscopic analyses.T...Fourteen unprecedented artificial Erythrina alkaloids were isolated from the Erythrina variegata,E.crista-galli and E.arborescens(Fabaceae).The structures of these alkaloids were determined by spectroscopic analyses.Their possible forma-tions were proposed.All isolated compounds showed no cytotoxicity and hypoglycemic activity at cell screening bioassay.展开更多
Five undescribed alkaloids were isolated from the seeds of Cephalotaxus oliveri along with 27 known ones.The new structures were elucidated based on spectroscopic data including 1D and 2D NMR,MS and calculated ECD spe...Five undescribed alkaloids were isolated from the seeds of Cephalotaxus oliveri along with 27 known ones.The new structures were elucidated based on spectroscopic data including 1D and 2D NMR,MS and calculated ECD spectra.Among them,(+)-acetylcephalofortine C was an enantiomeric Cephalotaxine alkaloids.The performed bioassay revealed that those alkaloids were not cytotoxic against cancer cells and had no neuroprotective properties in the HEI-OC-1 cells model.展开更多
Main observation and conclusion Two new pairs of monoterpenoid indole alkaloids(MIAs)enantiomers as well as their new congeners were isolated from stems of Tabernaemontana bovina Lour.(Apocynaceae).Their structures we...Main observation and conclusion Two new pairs of monoterpenoid indole alkaloids(MIAs)enantiomers as well as their new congeners were isolated from stems of Tabernaemontana bovina Lour.(Apocynaceae).Their structures were elucidated by spectroscopic analyses and confirmed by X-ray diffractions and computational calculations.Tabovine A,tabovine B and tabovines C-D possessed unprecedented 6/5/5/6/6,6/5/5/6/5 and 6/5/6/6/6 ring systems,respectively.It is the first time to report co-occurring enantiomers of MIAs.Additionally,the explanation concerning biogenesis of MIAs was provided.The findings would open a new window where we could disclose more diverse MIAs.展开更多
Phytochemical investigations on Tabernaemontana divaricata led to the isolation of seven undescribed monoterpenoid indole alkaloids,taberdicatines A-G(1-7).Taberdicatines A-C might be derived from Aspidosperma-type al...Phytochemical investigations on Tabernaemontana divaricata led to the isolation of seven undescribed monoterpenoid indole alkaloids,taberdicatines A-G(1-7).Taberdicatines A-C might be derived from Aspidosperma-type alkaloid,less skeletal carbons in 1-2 and an additional carbon in 3.Taberdicatines D-E(4-5)were attributed to Iboga alkaloids with enantiomeric skeleton,respectively.Alkaloid 3 could promote the neurite growth of mouse primary cortical neurons at the concentration of 5 pimol/L.展开更多
基金supported by the National Natural Science Foundation of China(21172225,31170334)the 973 Program of Ministry of Science and Technology of China(2009CB522300)the XiBuZhiGuang Project of Chinese Academy of Sciences,and the Young Academic and Technical Leader Raising Foundation of Yunnan Province(No.2010CI049).
文摘Four new monoterpenoid indole alkaloids,alstrostines C-F together with thirteen known alkaloids were isolated from the leaves and twigs of Alstonia rostrata.All structures of new compounds were elucidated based on NMR,FTIR,UV,and MS spectroscopic data.Alstrostines C-E might originate from keto-enol tautomerism of preakummicine during biogenetic pathway of akummicine.
基金supported by the Applied Basic Research Programs of Yunnan Province(No.2016FA030)the National Natural Science Foundation of China(31370377).
文摘Three new monoterpene indole alkaloids,3a-hydroxymethyl-ibogamine(1),3a-acetatemethoxyl-ibogamine(2),16a-hy-droxyl-ibogamine(3)together with six known alkaloids were isolated from the branches and leaves of Tabernaemontana divaricata(Apocynaceae).The structures of these alkaloids were determined by spectroscopic analyses.All isolated compounds showed no significant cytotoxicity against SGC-7901 gastric cancer,HeLa,and A-549 lung cancer cell lines(IC50>20μM).
基金This project was financially supported by the Young Academic and Technical Leader Raising Foundation of Yunnan Province(No.2010CI049).
文摘Five new alkaloids(1–5)were isolated from the leaves and twigs of Cephalotaxus lanceolata and C.fortunei var.alpina along with 24 known alkaloids.The new structures were elucidated based on spectroscopic data including 1D and 2D NMR,FTIR,UV and MS.These new alkaloids showed no cytotoxicity to HeLa,SGC-7901 gastric cancer,and A-549 lung cancer cell lines.
基金supported in part by the National Natural Science Foundation of China(31872677).
文摘Fourteen unprecedented artificial Erythrina alkaloids were isolated from the Erythrina variegata,E.crista-galli and E.arborescens(Fabaceae).The structures of these alkaloids were determined by spectroscopic analyses.Their possible forma-tions were proposed.All isolated compounds showed no cytotoxicity and hypoglycemic activity at cell screening bioassay.
基金funded in part by the National Natural Science Foundation of China (No.31872677).
文摘Five undescribed alkaloids were isolated from the seeds of Cephalotaxus oliveri along with 27 known ones.The new structures were elucidated based on spectroscopic data including 1D and 2D NMR,MS and calculated ECD spectra.Among them,(+)-acetylcephalofortine C was an enantiomeric Cephalotaxine alkaloids.The performed bioassay revealed that those alkaloids were not cytotoxic against cancer cells and had no neuroprotective properties in the HEI-OC-1 cells model.
基金This work was supported by the National Natural Science Foundation of China(Nos.31872677,31370377)Computational resources used in this work were supported in part by SciGrid,Chinese Academy of Sciences.
文摘Main observation and conclusion Two new pairs of monoterpenoid indole alkaloids(MIAs)enantiomers as well as their new congeners were isolated from stems of Tabernaemontana bovina Lour.(Apocynaceae).Their structures were elucidated by spectroscopic analyses and confirmed by X-ray diffractions and computational calculations.Tabovine A,tabovine B and tabovines C-D possessed unprecedented 6/5/5/6/6,6/5/5/6/5 and 6/5/6/6/6 ring systems,respectively.It is the first time to report co-occurring enantiomers of MIAs.Additionally,the explanation concerning biogenesis of MIAs was provided.The findings would open a new window where we could disclose more diverse MIAs.
基金the National Natural Science Foundation of China(Nos.31872677,31370377).Computational resources used in this work were supported in part by SciGrid,Chinese Academy of Sciences.
文摘Phytochemical investigations on Tabernaemontana divaricata led to the isolation of seven undescribed monoterpenoid indole alkaloids,taberdicatines A-G(1-7).Taberdicatines A-C might be derived from Aspidosperma-type alkaloid,less skeletal carbons in 1-2 and an additional carbon in 3.Taberdicatines D-E(4-5)were attributed to Iboga alkaloids with enantiomeric skeleton,respectively.Alkaloid 3 could promote the neurite growth of mouse primary cortical neurons at the concentration of 5 pimol/L.