Objective: To investigate the effect of dexmedetomidine on stress index, neurological function and related factors in patients after spinal surgery. Methods: A total of 120 patients who underwent spinal surgery in our...Objective: To investigate the effect of dexmedetomidine on stress index, neurological function and related factors in patients after spinal surgery. Methods: A total of 120 patients who underwent spinal surgery in our hospital from June 2015 to June 2018 were collected and randomly divided into the control group and the observation group, 60 cases in each group. The patients in the control group were given sufentanil for analgesia, while the patients in the observation group were given dexmedetomidine combined with sufentanil for analgesia. Before and after operation, the levels of adrenocortical hormone (ACTH), cortisol (Cor), serum insulin (Ins), peripheral blood nerve growth factor (NGF), neurotrophic factor (BDNF), adrenaline (Adr), norepinephrine (NE), endothelin-1 (ET-1), tumor necrosis factor-α(TNF-α) and C reactive protein (CRP) were measured and compared between the patients in the two groups. Result: The serum levels of ACTH, Cor, Ins, Adr, NE, ET-1, TNF-α and CRP of patients in the control group and observation group were significantly increased after operation, while the serum levels of ACTH, Cor, Ins, Adr, NE, ET-1, TNF-α and CRP of patients in the observation group were significantly lower than those in the control group. The serum levels of NGF and BDNF of patients in the observation group were significantly increased after operation. The serum levels of NGF and BDNF of patients in the control group were significantly decreased. Conclusion: Dexmedetomidine combined with sufentanil for spinal surgery analgesia can effectively control the levels of post-operative stress and reduce the influence on neurological function of patients. It can be used for clinical promotion.展开更多
文摘Objective: To investigate the effect of dexmedetomidine on stress index, neurological function and related factors in patients after spinal surgery. Methods: A total of 120 patients who underwent spinal surgery in our hospital from June 2015 to June 2018 were collected and randomly divided into the control group and the observation group, 60 cases in each group. The patients in the control group were given sufentanil for analgesia, while the patients in the observation group were given dexmedetomidine combined with sufentanil for analgesia. Before and after operation, the levels of adrenocortical hormone (ACTH), cortisol (Cor), serum insulin (Ins), peripheral blood nerve growth factor (NGF), neurotrophic factor (BDNF), adrenaline (Adr), norepinephrine (NE), endothelin-1 (ET-1), tumor necrosis factor-α(TNF-α) and C reactive protein (CRP) were measured and compared between the patients in the two groups. Result: The serum levels of ACTH, Cor, Ins, Adr, NE, ET-1, TNF-α and CRP of patients in the control group and observation group were significantly increased after operation, while the serum levels of ACTH, Cor, Ins, Adr, NE, ET-1, TNF-α and CRP of patients in the observation group were significantly lower than those in the control group. The serum levels of NGF and BDNF of patients in the observation group were significantly increased after operation. The serum levels of NGF and BDNF of patients in the control group were significantly decreased. Conclusion: Dexmedetomidine combined with sufentanil for spinal surgery analgesia can effectively control the levels of post-operative stress and reduce the influence on neurological function of patients. It can be used for clinical promotion.
